All Stories

  1. Ultrasound-guided renal artery administration of angiopoietin-1 RNA therapy slows the progression of preclinical WT1 glomerular disease

    Article • Science Translational Medicine, August 2026, American Association for the Advancement of Science

    David Long

  2. Response to the Letter to the Editor Entitled “Revisiting Vincristine for FSGS: Proof-of-Mechanism Arrives, but Whom Should we Treat?”

    Article • Kidney International Reports, March 2026, Elsevier

    David Long

  3. Letter to the Editor re: Genomic testing in paediatric urology: implications for diagnosis and management

    Article • Journal of Pediatric Urology, February 2026, Elsevier

    David Long

  4. A simple technique to create pre-vascularised delivery scaffolds for organoid therapies

    Article • November 2025, Cold Spring Harbor Laboratory Press

    David Long

  5. Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis

    Article • Kidney International Reports, November 2025, Elsevier

    David Long

  6. Nanobody Immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice

    Article • Journal of Nanobiotechnology, October 2025, Springer Science + Business Media

    David Long

  7. A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease

    Article • September 2025, openRxiv

    David Long

  8. Mapping the arterial vascular network in an intact human kidney using hierarchical phase-contrast tomography

    Article • npj Imaging, September 2025, Springer Science + Business Media

    David Long

  9. Neurite outgrowth inhibitor-B (Nogo-B) in physiology and disease.

    Article • Physiological Reviews, August 2025, American Physiological Society

    David Long, luigi gnudi

  10. Genetic lineage tracing identifies intermediate mesoderm as a novel contributor to mammalian kidney lymphatics

    Article • July 2025, Cold Spring Harbor Laboratory Press

    David Long

  11. Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection

    Article • Journal of Clinical Investigation, July 2025, American Society for Clinical Investigation

    David Long

  12. Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model

    Article • Disease Models & Mechanisms, April 2025, The Company of Biologists

    David Long

  13. Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease

    Article • Physiological Reports, January 2025, Wiley

    David Long

  14. Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosis

    Article • November 2024, Cold Spring Harbor Laboratory Press

    David Long

  15. Reversal of elevatedGli3in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesis

    Article • September 2024, Cold Spring Harbor Laboratory Press

    David Long

  16. Cell Catcher: A New Method to Extract and Preserve Live Renal Cells from Urine

    Article • Kidney360, September 2024, Wolters Kluwer Health

    David Long

  17. Single‐cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease

    Article • The Journal of Pathology, August 2024, Wiley

    David Long

  18. SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart

    Article • Basic Research in Cardiology, August 2024, Springer Science + Business Media

    David Long

  19. Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease

    Article • Physiological Reports, July 2024, Wiley

    David Long

  20. A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

    Article • March 2024, Cold Spring Harbor Laboratory Press

    David Long

  21. A microfluidic platform integrating functional vascularized organoids-on-chip

    Article • Nature Communications, February 2024, Springer Science + Business Media

    David Long

  22. Cell Catcher: a new method to extract and preserve live renal cells from urine

    Article • September 2023, Cold Spring Harbor Laboratory Press

    David Long

  23. Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

    Article • March 2023, Cold Spring Harbor Laboratory Press

    David Long

  24. Hyperglycemic exacerbation of myocardial infarction through SGLT1 - a glucose paradox

    Article • March 2023, Cold Spring Harbor Laboratory Press

    David Long

  25. Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

    Article • October 2022, Cold Spring Harbor Laboratory Press

    David Long

  26. Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

    Article • Scientific Reports, July 2022, Springer Science + Business Media

    David Long

  27. The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention

    Article • JCI Insight, February 2022, American Society for Clinical Investigation

    David Long

  28. ­­­Kidney organoids recapitulate human basement membrane assembly in health and disease

    Article • eLife, January 2022, eLife

    David Long

  29. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

    Article • Nature Chemical Biology, November 2021, Springer Science + Business Media

    David Long

  30. Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder

    Article • Scientific Reports, July 2021, Springer Science + Business Media

    David Long

  31. Identification of an Altered Matrix Signature in Kidney Aging and Disease

    Article • Journal of the American Society of Nephrology, May 2021, American Society of Nephrology

    David Long

  32. Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

    Article • May 2021, Cold Spring Harbor Laboratory Press

    David Long

  33. Mechanisms and cell lineages in lymphatic vascular development

    Article • Angiogenesis, April 2021, Springer Science + Business Media

    David Long, Professor Christiana Ruhrberg

  34. The Biological Significance and Implications of Planar Cell Polarity for Nephrology

    Article • Frontiers in Physiology, February 2021, Frontiers

    David Long

  35. Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

    Article • February 2021, Cold Spring Harbor Laboratory Press

    David Long

  36. Antenatal biological models in the characterization and research of congenital lower urinary tract disorders

    Article • Journal of Pediatric Urology, November 2020, Elsevier

    David Long

  37. Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling

    Article • Cellular Signalling, August 2020, Elsevier

    David Long

  38. Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    David Long, Kazunori Tomita

  39. Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases

    Article • Journal of the American Society of Nephrology, April 2020, American Society of Nephrology

    David Long

  40. Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease

    Article • Pediatric Nephrology, January 2020, Springer Science + Business Media

    David Long, Dr Evgenia Preka

  41. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Article • eLife, December 2019, eLife

    David Long

  42. Generating Mutant Renal Cell Lines Using CRISPR Technologies

    Article • November 2019, Springer Science + Business Media

    David Long, Marian Seda

  43. Tissue Clearing and Deep Imaging of the Kidney Using Confocal and Two-Photon Microscopy

    Article • November 2019, Springer Science + Business Media

    David Long

  44. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

    Article • Diabetes, June 2019, American Diabetes Association

    luigi gnudi, David Long

  45. Arterial “inflammaging” drives vascular calcification in children on dialysis

    Article • Kidney International, April 2019, Elsevier

    David Long

  46. SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart

    Article • JACC Basic to Translational Science, February 2019, Elsevier

    David Long

  47. Planar cell polarity in organ formation

    Article • Current Opinion in Cell Biology, December 2018, Elsevier

    David Long

  48. Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury

    Article • The Journal of Pathology, November 2018, Wiley

    David Long

  49. In vivo three-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models

    Article • AJP Renal Physiology, June 2018, American Physiological Society

    David Long

  50. Thymosin-β4: A key modifier of renal disease

    Article • Expert Opinion on Biological Therapy, May 2018, Taylor & Francis

    David Long

  51. Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system

    Article • Cell Death Discovery, February 2018, Springer Science + Business Media

    David Long

  52. HeterozygousVangl2Looptailmice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

    Article • Disease Models & Mechanisms, February 2017, The Company of Biologists

    David Long, Darcy Wagner

  53. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning

    Article • Kidney International, December 2016, Elsevier

    David Long

  54. Vascular growth factors play critical roles in kidney glomeruli

    Article • Clinical Science, November 2015, Portland Press Ltd.

    David Long, luigi gnudi

  55. The role of thymosin-β4 in kidney disease

    Article • Expert Opinion on Biological Therapy, June 2015, Informa Healthcare

    David Long

  56. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases

    Article • Journal of the American Society of Nephrology, June 2015, American Society of Nephrology

    David Long

  57. HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype

    Article • Journal of the American Society of Nephrology, May 2014, American Society of Nephrology

    David Long

  58. Planar cell polarity and the kidney

    Article • Nephrology Dialysis Transplantation, November 2013, Oxford University Press (OUP)

    David Long

  59. Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease

    Article • Journal of the American Society of Nephrology, September 2013, American Society of Nephrology

    David Long, luigi gnudi

  60. Albuminuria is associated with too few glomeruli and too much testosterone

    Article • Kidney International, June 2013, Elsevier

    David Long, luigi gnudi

  61. Circulating Angiopoietin-2 Is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis

    Article • PLOS One, February 2013, PLOS

    David Long

  62. Mechanistic Insights into Vascular Calcification in CKD

    Article • Journal of the American Society of Nephrology, November 2012, American Society of Nephrology

    David Long

  63. Angiogenesis and autosomal dominant polycystic kidney disease

    Article • Pediatric Nephrology, September 2012, Springer Science + Business Media

    David Long

  64. The renal archaeologist: digging for clues in archived tissues to understand diabetic kidney disease

    Article • Nephrology Dialysis Transplantation, February 2012, Oxford University Press (OUP)

    David Long

  65. Restoring the renal microvasculature to treat chronic kidney disease

    Article • Nature Reviews Nephrology, February 2012, Springer Science + Business Media

    David Long

  66. An unusual case of pediatric shortness of breath—questions

    Article • Pediatric Nephrology, October 2011, Springer Science + Business Media

    David Long

  67. Selective Stimulation of VEGFR2 Accelerates Progressive Renal Disease

    Article • American Journal Of Pathology, July 2011, Elsevier

    David Long

  68. Modified Citrus Pectin Reduces Galectin-3 Expression and Disease Severity in Experimental Acute Kidney Injury

    Article • PLOS One, April 2011, PLOS

    David Long

  69. The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

    Article • Human Molecular Genetics, September 2010, Oxford University Press (OUP)

    David Long

  70. Mutations in HPSE2 Cause Urofacial Syndrome

    Article • The American Journal of Human Genetics, June 2010, Elsevier

    David Long

  71. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog

    Article • AJP Renal Physiology, February 2010, American Physiological Society

    David Long

  72. Sphingosine kinase-1: a potential mediator of renal fibrosis

    Article • Kidney International, October 2009, Elsevier

    David Long

  73. Abnormal Angiogenesis in Diabetic Nephropathy

    Article • Diabetes, June 2009, American Diabetes Association

    David Long

  74. Unraveling the Genetic Landscape of Bladder Development in Mice

    Article • The Journal of Urology, May 2009, Wolters Kluwer Health

    David Long

  75. HNF1BMutations Associate with Hypomagnesemia and Renal Magnesium Wasting

    Article • Journal of the American Society of Nephrology, April 2009, American Society of Nephrology

    David Long

  76. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism

    Article • AJP Renal Physiology, January 2009, American Physiological Society

    David Long

  77. Roles of Angiopoietins in Kidney Development and Disease: Figure 1.

    Article • Journal of the American Society of Nephrology, September 2008, American Society of Nephrology

    David Long, luigi gnudi

  78. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

    Article • Development, August 2008, The Company of Biologists

    David Long

  79. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury

    Article • Kidney International, August 2008, Elsevier

    David Long, luigi gnudi

  80. Podocyte-Specific Expression of Angiopoietin-2 Causes Proteinuria and Apoptosis of Glomerular Endothelia

    Article • Journal of the American Society of Nephrology, July 2007, American Society of Nephrology

    David Long, luigi gnudi

  81. Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo

    Article • Physiological Genomics, January 2007, American Physiological Society

    David Long

  82. Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension

    Article • AJP Renal Physiology, December 2006, American Physiological Society

    David Long

  83. Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment

    Article • Journal of Pediatric Urology, August 2006, Elsevier

    David Long

  84. Vascular endothelial growth factor stimulates embryonic urinary bladder development in organ culture

    Article • BJU International, July 2006, Wiley

    David Long

  85. Human Vascular Smooth Muscle Cells Express a Urate Transporter

    Article • Journal of the American Society of Nephrology, June 2006, American Society of Nephrology

    David Long

  86. Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging

    Article • Kidney International, November 2005, Elsevier

    David Long

  87. IL-10 Suppresses Chemokines, Inflammation, and Fibrosis in a Model of Chronic Renal Disease

    Article • Journal of the American Society of Nephrology, October 2005, American Society of Nephrology

    David Long

  88. How Does Angiotensin II Cause Renal Injury?

    Article • Hypertension, April 2004, Wolters Kluwer Health

    David Long

  89. Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis

    Article • Kidney International, June 2002, Elsevier

    David Long