All Stories

  1. A simple technique to create pre-vascularised delivery scaffolds for organoid therapies

    Article • November 2025, Cold Spring Harbor Laboratory Press

    David Long

  2. Neurite outgrowth inhibitor-B (Nogo-B) in physiology and disease.

    Article • Physiological Reviews, August 2025, American Physiological Society

    David Long, luigi gnudi

  3. Genetic lineage tracing identifies intermediate mesoderm as a novel contributor to mammalian kidney lymphatics

    Article • July 2025, Cold Spring Harbor Laboratory Press

    David Long

  4. Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection

    Article • Journal of Clinical Investigation, July 2025, American Society for Clinical Investigation

    David Long

  5. Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model

    Article • Disease Models & Mechanisms, April 2025, The Company of Biologists

    David Long

  6. Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease

    Article • Physiological Reports, January 2025, Wiley

    David Long

  7. Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosis

    Article • November 2024, Cold Spring Harbor Laboratory Press

    David Long

  8. Reversal of elevatedGli3in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesis

    Article • September 2024, Cold Spring Harbor Laboratory Press

    David Long

  9. Cell Catcher: A New Method to Extract and Preserve Live Renal Cells from Urine

    Article • Kidney360, September 2024, Wolters Kluwer Health

    David Long

  10. Single‐cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease

    Article • The Journal of Pathology, August 2024, Wiley

    David Long

  11. SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart

    Article • Basic Research in Cardiology, August 2024, Springer Science + Business Media

    David Long

  12. Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease

    Article • Physiological Reports, July 2024, Wiley

    David Long

  13. A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

    Article • March 2024, Cold Spring Harbor Laboratory Press

    David Long

  14. A microfluidic platform integrating functional vascularized organoids-on-chip

    Article • Nature Communications, February 2024, Springer Science + Business Media

    David Long

  15. Cell Catcher: a new method to extract and preserve live renal cells from urine

    Article • September 2023, Cold Spring Harbor Laboratory Press

    David Long

  16. Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

    Article • March 2023, Cold Spring Harbor Laboratory Press

    David Long

  17. Hyperglycemic exacerbation of myocardial infarction through SGLT1 - a glucose paradox

    Article • March 2023, Cold Spring Harbor Laboratory Press

    David Long

  18. Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

    Article • October 2022, Cold Spring Harbor Laboratory Press

    David Long

  19. Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

    Article • Scientific Reports, July 2022, Springer Science + Business Media

    David Long

  20. The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention

    Article • JCI Insight, February 2022, American Society for Clinical Investigation

    David Long

  21. ­­­Kidney organoids recapitulate human basement membrane assembly in health and disease

    Article • eLife, January 2022, eLife

    David Long

  22. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

    Article • Nature Chemical Biology, November 2021, Springer Science + Business Media

    David Long

  23. Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder

    Article • Scientific Reports, July 2021, Springer Science + Business Media

    David Long

  24. Identification of an Altered Matrix Signature in Kidney Aging and Disease

    Article • Journal of the American Society of Nephrology, May 2021, American Society of Nephrology

    David Long

  25. Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

    Article • May 2021, Cold Spring Harbor Laboratory Press

    David Long

  26. Mechanisms and cell lineages in lymphatic vascular development

    Article • Angiogenesis, April 2021, Springer Science + Business Media

    David Long, Professor Christiana Ruhrberg

  27. The Biological Significance and Implications of Planar Cell Polarity for Nephrology

    Article • Frontiers in Physiology, February 2021, Frontiers

    David Long

  28. Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

    Article • February 2021, Cold Spring Harbor Laboratory Press

    David Long

  29. Antenatal biological models in the characterization and research of congenital lower urinary tract disorders

    Article • Journal of Pediatric Urology, November 2020, Elsevier

    David Long

  30. Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling

    Article • Cellular Signalling, August 2020, Elsevier

    David Long

  31. Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    David Long, Kazunori Tomita

  32. Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases

    Article • Journal of the American Society of Nephrology, April 2020, American Society of Nephrology

    David Long

  33. Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease

    Article • Pediatric Nephrology, January 2020, Springer Science + Business Media

    David Long, Dr Evgenia Preka

  34. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Article • eLife, December 2019, eLife

    David Long

  35. Generating Mutant Renal Cell Lines Using CRISPR Technologies

    Article • November 2019, Springer Science + Business Media

    David Long, Marian Seda

  36. Tissue Clearing and Deep Imaging of the Kidney Using Confocal and Two-Photon Microscopy

    Article • November 2019, Springer Science + Business Media

    David Long

  37. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

    Article • Diabetes, June 2019, American Diabetes Association

    luigi gnudi, David Long

  38. Arterial “inflammaging” drives vascular calcification in children on dialysis

    Article • Kidney International, April 2019, Elsevier

    David Long

  39. SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart

    Article • JACC Basic to Translational Science, February 2019, Elsevier

    David Long

  40. Planar cell polarity in organ formation

    Article • Current Opinion in Cell Biology, December 2018, Elsevier

    David Long

  41. Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury

    Article • The Journal of Pathology, November 2018, Wiley

    David Long

  42. In vivo three-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models

    Article • AJP Renal Physiology, June 2018, American Physiological Society

    David Long

  43. Thymosin-β4: A key modifier of renal disease

    Article • Expert Opinion on Biological Therapy, May 2018, Taylor & Francis

    David Long

  44. Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system

    Article • Cell Death Discovery, February 2018, Springer Science + Business Media

    David Long

  45. HeterozygousVangl2Looptailmice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

    Article • Disease Models & Mechanisms, February 2017, The Company of Biologists

    David Long, Darcy Wagner

  46. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning

    Article • Kidney International, December 2016, Elsevier

    David Long

  47. Vascular growth factors play critical roles in kidney glomeruli

    Article • Clinical Science, November 2015, Portland Press Ltd.

    David Long, luigi gnudi

  48. The role of thymosin-β4 in kidney disease

    Article • Expert Opinion on Biological Therapy, June 2015, Informa Healthcare

    David Long

  49. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases

    Article • Journal of the American Society of Nephrology, June 2015, American Society of Nephrology

    David Long

  50. HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype

    Article • Journal of the American Society of Nephrology, May 2014, American Society of Nephrology

    David Long

  51. Planar cell polarity and the kidney

    Article • Nephrology Dialysis Transplantation, November 2013, Oxford University Press (OUP)

    David Long

  52. Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease

    Article • Journal of the American Society of Nephrology, September 2013, American Society of Nephrology

    David Long, luigi gnudi

  53. Albuminuria is associated with too few glomeruli and too much testosterone

    Article • Kidney International, June 2013, Elsevier

    David Long, luigi gnudi

  54. Circulating Angiopoietin-2 Is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis

    Article • PLOS One, February 2013, PLOS

    David Long

  55. Mechanistic Insights into Vascular Calcification in CKD

    Article • Journal of the American Society of Nephrology, November 2012, American Society of Nephrology

    David Long

  56. Angiogenesis and autosomal dominant polycystic kidney disease

    Article • Pediatric Nephrology, September 2012, Springer Science + Business Media

    David Long

  57. The renal archaeologist: digging for clues in archived tissues to understand diabetic kidney disease

    Article • Nephrology Dialysis Transplantation, February 2012, Oxford University Press (OUP)

    David Long

  58. Restoring the renal microvasculature to treat chronic kidney disease

    Article • Nature Reviews Nephrology, February 2012, Springer Science + Business Media

    David Long

  59. An unusual case of pediatric shortness of breath—questions

    Article • Pediatric Nephrology, October 2011, Springer Science + Business Media

    David Long

  60. Selective Stimulation of VEGFR2 Accelerates Progressive Renal Disease

    Article • American Journal Of Pathology, July 2011, Elsevier

    David Long

  61. Modified Citrus Pectin Reduces Galectin-3 Expression and Disease Severity in Experimental Acute Kidney Injury

    Article • PLOS One, April 2011, PLOS

    David Long

  62. The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

    Article • Human Molecular Genetics, September 2010, Oxford University Press (OUP)

    David Long

  63. Mutations in HPSE2 Cause Urofacial Syndrome

    Article • The American Journal of Human Genetics, June 2010, Elsevier

    David Long

  64. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog

    Article • AJP Renal Physiology, February 2010, American Physiological Society

    David Long

  65. Sphingosine kinase-1: a potential mediator of renal fibrosis

    Article • Kidney International, October 2009, Elsevier

    David Long

  66. Abnormal Angiogenesis in Diabetic Nephropathy

    Article • Diabetes, June 2009, American Diabetes Association

    David Long

  67. Unraveling the Genetic Landscape of Bladder Development in Mice

    Article • The Journal of Urology, May 2009, Wolters Kluwer Health

    David Long

  68. HNF1BMutations Associate with Hypomagnesemia and Renal Magnesium Wasting

    Article • Journal of the American Society of Nephrology, April 2009, American Society of Nephrology

    David Long

  69. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism

    Article • AJP Renal Physiology, January 2009, American Physiological Society

    David Long

  70. Roles of Angiopoietins in Kidney Development and Disease: Figure 1.

    Article • Journal of the American Society of Nephrology, September 2008, American Society of Nephrology

    David Long, luigi gnudi

  71. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

    Article • Development, August 2008, The Company of Biologists

    David Long

  72. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury

    Article • Kidney International, August 2008, Elsevier

    David Long, luigi gnudi

  73. Podocyte-Specific Expression of Angiopoietin-2 Causes Proteinuria and Apoptosis of Glomerular Endothelia

    Article • Journal of the American Society of Nephrology, July 2007, American Society of Nephrology

    David Long, luigi gnudi

  74. Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo

    Article • Physiological Genomics, January 2007, American Physiological Society

    David Long

  75. Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension

    Article • AJP Renal Physiology, December 2006, American Physiological Society

    David Long

  76. Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment

    Article • Journal of Pediatric Urology, August 2006, Elsevier

    David Long

  77. Vascular endothelial growth factor stimulates embryonic urinary bladder development in organ culture

    Article • BJU International, July 2006, Wiley

    David Long

  78. Human Vascular Smooth Muscle Cells Express a Urate Transporter

    Article • Journal of the American Society of Nephrology, June 2006, American Society of Nephrology

    David Long

  79. Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging

    Article • Kidney International, November 2005, Elsevier

    David Long

  80. IL-10 Suppresses Chemokines, Inflammation, and Fibrosis in a Model of Chronic Renal Disease

    Article • Journal of the American Society of Nephrology, October 2005, American Society of Nephrology

    David Long

  81. How Does Angiotensin II Cause Renal Injury?

    Article • Hypertension, April 2004, Wolters Kluwer Health

    David Long

  82. Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis

    Article • Kidney International, June 2002, Elsevier

    David Long