All Stories

  1. Editing sugars: decatungstate photocatalyzed site- and stereoselective C–H functionalization in β-fucosides
  2. Increasing the Chemical Space of L-SIGN Specific Glycomimetics
  3. Expanding the Chemical Space of Sugar Frameworks by Quaternization of the Anomeric Carbon Atom
  4. Increasing the chemical space of L-SIGN specific glycomimetics
  5. Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections: A Biophysical Study
  6. Synthesis of α-arylglycosides by Ni-photoredox arylation of sugars with an organic photocatalyst
  7. Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
  8. Polyvalent Glycomimetic-Gold Nanoparticles Revealing Critical Roles of Glycan Display on Multivalent Lectin–Glycan Interaction Biophysics and Antiviral Properties
  9. Polyvalent Glycomimetic-Gold Nanoparticle Conjugates reveal effects of glycan display on Multivalent Lectin-Glycan Interactions
  10. Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor
  11. Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from Burkholderia cenocepacia
  12. Scalemic natural products
  13. Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of Burkholderia cenocepacia’s BC2L-C Lectin
  14. Front Cover: Precision Glycodendrimers for DC‐SIGN Targeting (Eur. J. Org. Chem. 29/2022)
  15. Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies
  16. Precision Glycodendrimers for DC‐SIGN Targeting**
  17. Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors
  18. DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist
  19. One pot synthesis ofthio-glycosidesviaaziridine opening reactions
  20. Chemo‐Enzymatic Synthesis of S. mansoni O‐Glycans and Their Evaluation as Ligands for C‐Type Lectin Receptors MGL, DC‐SIGN, and DC‐SIGNR
  21. Interfering with the Sugar Code: Ten Years Later
  22. BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information
  23. Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface
  24. Development of c-type lectin oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface
  25. Design and synthesis of glycomimetics: Recent advances
  26. Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase
  27. Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition
  28. Glycodendron–rhenium complexes as luminescent probes for lectin sensing
  29. Observation of a Tricyclic[4.1.0.02,4]heptane During a Michael Addition-Ring Closure Reaction and a Computational Study on Its Mechanism of Formation
  30. From optimized monovalent ligands to size-controlled dendrimers: an efficient strategy towards high-activity DC-SIGN antagonists
  31. Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics
  32. Frontispiece: Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads
  33. Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads
  34. Glyco-functionalized dinuclear rhenium(i) complexes for cell imaging
  35. Clickable Polymeric Coating for Glycan Microarrays
  36. Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants
  37. A relevant pharmacological target in TBI
  38. A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors
  39. Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity
  40. Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives
  41. Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands
  42. Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core
  43. Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin
  44. Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering
  45. Stereoselective innovative synthesis and biological evaluation of new real carba analogues of minimal epitope Manα(1,2)Man as DC-SIGN inhibitors
  46. Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold
  47. Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating
  48. Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands
  49. Carbohydrates: A phenol sandwich fights diabetes
  50. New “clickable” polymeric coating for glycan microarrays
  51. Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods
  52. Effective Targeting of DC-SIGN by α-Fucosylamide Functionalized Gold Nanoparticles
  53. Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR
  54. Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design
  55. Synthesis of potential allosteric modulators of Hsp90 by chemical glycosylation of Eupomatenoid-6
  56. A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus
  57. Pseudo-Mannosylated DC-SIGN Ligands as Potential Adjuvants for HIV Vaccines
  58. A Facile Synthesis of α-N-Ribosyl-Asparagine and α-N-Ribosyl-Glutamine Building Blocks
  59. Synthesis and Characterization of Linker-Armed Fucose-Based Glycomimetics
  60. Selective Targeting of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN) with Mannose-Based Glycomimetics: Synthesis and Interaction Studies of Bis(benzylamide) Derivatives of a Pseudomannobioside
  61. Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design
  62. Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors
  63. Multivalent glycoconjugates as anti-pathogenic agents
  64. Targeting MBL in cerebral ischemia induces long lasting protection with a wide therapeutic window
  65. Targeting Mannose-Binding Lectin Confers Long-Lasting Protection With a Surprisingly Wide Therapeutic Window in Cerebral Ischemia
  66. Stereoselective Synthesis of α- and β-Glycofuranosyl Amides by Traceless Ligation of Glycofuranosyl Azides
  67. Both El Tor and classical cholera toxin bind blood group determinants
  68. A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models
  69. α-N-Linked glycopeptides: conformational analysis and bioactivity as lectin ligands
  70. Mannose binding lectin as a target for cerebral ischemic injury
  71. 2-Azidoethoxy derivatives of 2-aminocyclohexanecarboxylic acids (ACHC): interesting building blocks for the synthesis of cyclic β-peptide conjugates
  72. Pseudosaccharide Functionalized Dendrimers as Potent Inhibitors of DC-SIGN Dependent Ebola Pseudotyped Viral Infection
  73. Synthesis of α-N-Linked Glycopeptides
  74. Stereoselective synthesis of N-galactofuranosyl amides
  75. Insights into molecular recognition of LewisX mimics by DC-SIGN using NMR and molecular modelling
  76. Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin
  77. Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists
  78. DFG-in and DFG-out homology models of TrkB kinase receptor: Induced-fit and ensemble docking
  79. An assay for functional dendritic cell-specific ICAM-3-grabbing nonintegrin (DC–SIGN) inhibitors of human dendritic cell adhesion
  80. Synthesis of non glycosidic nucleobase-sugar mimetics
  81. HIV microbicides: state-of-the-art and new perspectives on the development of entry inhibitors
  82. Monovalent and bivalent N-fucosyl amides as high affinity ligands for Pseudomonas aeruginosa PA-IIL lectin
  83. Synthesis and Affinity Evaluation of a Small Library of Bidentate Cholera Toxin Ligands: Towards Nonhydrolyzable Ganglioside Mimics
  84. Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation
  85. Stereoselective Synthesis ofN-Glycosyl Amino Acids by Traceless Staudinger Ligation of Unprotected Glycosyl Azides
  86. Interfering with the Sugar Code: Design and Synthesis of Oligosaccharide Mimics
  87. Synthesis of Novel DC‐SIGN Ligands with an α‐Fucosylamide Anchor
  88. Stereoselective synthesis of glycosyl amides by traceless Staudinger ligation of unprotected glycosyl azides
  89. Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility
  90. Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic
  91. First round of a focused library of cholera toxin inhibitors
  92. 1,2‐Mannobioside Mimic: Synthesis, DC‐SIGN Interaction by NMR and Docking, and Antiviral Activity
  93. A Simple Model System for the Study of Carbohydrate−Aromatic Interactions
  94. Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies
  95. Synthesis and Conformational Analysis of Galactose-Derived Bicyclic Scaffolds
  96. A facile stereoselective synthesis of α-glycosyl ureas
  97. Traceless Staudinger Ligation of Glycosyl Azides with Triaryl Phosphines:  Stereoselective Synthesis of Glycosyl Amides †
  98. Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids
  99. A Synthetic Divalent Cholera Toxin Glycocalix[4]arene Ligand Having Higher Affinity than Natural GM1 Oligosaccharide
  100. Neo-glycoconjugates: stereoselective synthesis of α-glycosyl amides via Staudinger ligation reactions
  101. Synthesis, Conformational Studies and Mannosidase Stability of a Mimic of 1,2-Mannobioside
  102. Intramolecular Carbohydrate-Aromatic Interactions and Intermolecular van der Waals Interactions Enhance the Molecular Recognition Ability of GM1 Glycomimetics for Cholera Toxin
  103. Conformational analysis and dynamics of mannobiosides and mannotriosides using Monte Carlo/stochastic dynamics simulations
  104. Selective synthesis of anomeric α-glycosyl acetamides via intramolecular Staudinger ligation of the α-azides
  105. Synthesis and cholera toxin binding properties of multivalent GM1 mimicsElectronic supplementary information (ESI) available: characterization of the polyvalent compounds ? imide by-products. See http://www.rsc.org/suppdata/ob/b4/b405344c/
  106. Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin
  107. Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residueElectronic supplementary information (ESI) available: synthetic details, product characterisations and full NOE contact list. See http://www.rsc.org/suppdata/ob/b2/b21...
  108. Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds
  109. Stereoselective Synthesis of Conformationally Constrained Cyclohexanediols:  A Set of Molecular Scaffolds for the Synthesis of Glycomimetics
  110. Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety
  111. Improved synthesis of both enantiomers of trans-cyclohex-4-ene-1,2-dicarboxylic acid
  112. Structural Basis for the Resistance of Tay-Sachs Ganglioside GM2 to Enzymatic Degradation
  113. Sugar Mimics:  An Artificial Receptor for Cholera Toxin
  114. A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates
  115. Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents
  116. Enantioselective conjugate additions of silylketene acetals to 2-carboxycyclopentenones promoted by chiral Ti complexes
  117. Simulation of Protein−Sugar Interactions:  A Computational Model of the Complex between Ganglioside GM1 and the Heat-Labile Enterotoxin of Escherichia coli †
  118. Computational studies on the aldol-type addition of boron enolates to imines: An ab-initio approach
  119. Conformational analysis of saccharides with Monte Carlo/stochastic dynamics simulations
  120. Enantioselective mukaiyama-michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(Oxazoline)-Cu(II) complexes
  121. Stereoselective conjugate addition of lithium and titanium enolates to γ - alkoxy enones
  122. The rational design and systematic analysis of asymmetric aldol reactions using enol borinates: Applications of transition state computer modelling
  123. Conformational Analysis of GM1 Oligosaccharide in Water Solution with a New Set of Parameters for the Neu5Ac Moiety
  124. Mechanistic insights from ab initio calculations on a nitrogen analogue of the boron-mediated aldol reaction
  125. Enantioselective michael-mukaiyama additions of silylketene acetals to 2-carboxycyclopentenones promoted by chiral Ti complexes
  126. Stereoselective conjugate addition of propionate Ti ate enolate to unsaturated chiral ketones: A new insight in the reaction mechanism
  127. Titanium Ate Enolate Complexes: An NMR Study
  128. Origins of stereoselectivity in the addition of allyl- and crotylboronates to aldehydes : the development and application of a force field model of the transition state
  129. Computer-assisted design of chiral boron enolates: The role of ate complexes in determining aldol stereoselectivity.
  130. Origins of stereoselectivity in the addition of chiral allyl- and crotylboranes to aldehydes: the development and application of a force field model of the transition state
  131. Origins of π-face selectivity in the aldol reactions of chiral E-enol borinates: a computational study using transition state modelling.
  132. Acceleration of the conjugate addition of Ti “ate” enolates via lewis acid catalysis.
  133. A computational study of the 1,4-addition of lithium enolates to conjugated carbonyl compounds
  134. The rational design of highly stereoselective boron enolates using transition-state computer modeling: a novel, asymmetric anti aldol reaction for ketones
  135. Stereoselective Michael additions of titanium “ate” complexes of ketone and ester enolates
  136. Norephedrine derived oxazolidines as chiral acylating agents: An NMR study of the intermediate cations.
  137. Developing a force field for the transition state of the aldol reaction of enolborinates: Evaluation of the use of fixed point charges.
  138. Addition of racemic alkoxyallylstannanes to an enantiomerically pure 2-methoxyoxazolidine: an example of combined mutual diastereoface selection and kinetic resolution
  139. Highly stereoselective acetylations via norephedrine derived oxazolidines.
  140. Asymmetric hydrogenation of 3-methyl-fumaric and maleic ester monoaldehydes protected as neph-derived oxazolidines
  141. Highly selective binding of simple peptides by a C3 macrotricyclic receptor
  142. A computational study of the 1,4-addition of lithium enolates to conjugated carbonyl compounds.
  143. Origins of stereoselectivity in chiral boron enolate aldol reactions: A computational study using transition state modellings
  144. Transition-state modeling of the aldol reaction of boron enolates: a force field approach
  145. Stereoselective synthesis of statin analogues.
  146. Norephedrine derived 2-methoxy oxazolidines as chiral formyl cation equivalents
  147. Asymmetric synthesis of malic acid-type synthons VIA chiral norephedrine-derived oxazolidines
  148. 1,4-addition to α,β-unsaturated carbonyl compounds bearing a γ-stereocenter: A molecular mechanics model for steric interactions in the transition state.
  149. Allylic stereocentre directed cyclopropanation. A new highly enantioselective synthesis of hemicaronic aldehyde
  150. Norephedrine-derived 2-alkenyloxazolidines: stereochemistry of cyclization and allylic stereocenter directed asymmetric conjugate addition
  151. Catalytic osmylation of electron poor allylic alcohols and ethers.
  152. Asymmetric synthesis of functionalized α -amino-β-hydroxy acids via chiral norephedrine-derived oxazolidines
  153. Magnesium bromide-promoted addition of heterosubstituted methylketene silyl acetals to alkoxy aldehydes. Diastereoselective synthesis of 3,4-syn-2-methylene- and 2-(alkoxymethyl)-3-hydroxy-4-alkoxy esters
  154. Conformational analysis of oxazolidines by molecular and quantum mechanics and NMR spectroscopy
  155. Allylic stereocenter directed asymmetric conjugate addition. Enantioselective synthesis of 3-alkylsuccinaldehydic acid methyl esters
  156. Lewis acid mediated aldol condensations using thioester silyl ketene acetals
  157. Synthetic opportunities offered by anti .alpha.-methylene-.beta.-hydroxy-.gamma.-alkoxy esters: stereoselective reactions at the double bond
  158. Enantioselective synthesis of anti-.alpha.-methyl-.beta.-hydroxy esters through titanium tetrachloride-mediated aldol condensation
  159. Stereoselective aldol reactions using ticl4 as stereochemical template
  160. Stereoselective aldol additions to α-alkoxy aldehydes using thioester silyl ketene acetals,
  161. Lewis acid promoted aldol additions of α-thiosilylketeneacetals to α-alkoxy aldehydes: diastereoselective synthesis of -α-methylene-β-hydroxy-∂-alkoxy esters.
  162. High diastereoselectivity in lewis acid mediated aldol condensations using thioester silyl ketene acetals.
  163. High diastereoface selection in an ester enolate addition to .alpha.-alkoxy aldehydes: stereoselective synthesis of .alpha.-methylene-.beta.-hydroxy-.gamma.-alkoxy esters
  164. Ethyl-(r)-(4-methylphenylsulfinyl)-n-methoxy acetimidate a useful chiral acetate equivalent in aldol type condensations
  165. Stereoselective aldol condensations via alkenyloxy dialkoxyboranes: synthetic applications using thioesters
  166. Design and synthesis of glycomimetics