All Stories

  1. Substitution of dichloromethane with greener solvents for the preparation of thioglycosides and glycosyl azides, and for a glycosylation reaction. Deacetylation in ethanol-ethyl acetate
  2. N‐Glycosyl Triazoline Glycomimetics via Huisgen Cycloaddition With an Electron‐Deficient Alkene and BF 3 ‐Catalysed Triazoline Fragmentation to Aziridines
  3. Synthesis of Azidosugar and Thioglycoside Building Blocks Using EtOAc, EtOH and Cyclopentyl Methyl Ether (CPME) as Greener Solvents
  4. Design, Synthesis and Biophysical Evaluation of Sialyl Triazoles as Glycomimetic Ligands for Siglec-8. Sulfonate is a Viable Replacement for Sulfate
  5. Synthesis of β-d-C-Galactopyranosyl Compounds Including Constrained Derivatives from Clickable Building Blocks and Evaluation as Ligands for Galectins
  6. Synthesis of an N ‐Galactosyl Norbornane Aziridine and its Potent Mixed Inhibition of Aspergillus oryzae β‐Galactosidase
  7. Cover Feature: Application of Sublimation in the Synthesis and Crystal Growth of Organosulfones (Chem. Eur. J. 36/2024)
  8. Application of Sublimation in the Synthesis and Crystal Growth of Organosulfones
  9. Flow Chemistry for Synthesis of 2-(C-Glycosyl)acetates from Pyranoses via Tandem Wittig and Michael Reactions
  10. Beyond the Crystal Structure of Human Macrophage C-Type Lectin
  11. Small lectin ligands as a basis for applications in glycoscience and glycomedicine
  12. Synthesis of C-glycoside analogues of isopropyl β-d-1-thiogalactopyranoside (IPTG) and 1-β-d-galactopyranosyl-2-methylpropane. Conformational analysis and evaluation as inhibitors of the lac repressor in E. coli and ...
  13. Flow chemistry based catalytic hydrogenation for improving the synthesis of 1-deoxynojirimycin (DNJ) from an l-sorbose derived precursor
  14. MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response
  15. Targeting osteoarthritis-associated galectins and an induced effector class by a ditopic bifunctional reagent: Impact of its glycan part on binding measured in the tissue context
  16. Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis
  17. A cell free biomembrane platform for multimodal study of influenza virus hemagglutinin and for evaluation of entry-inhibitors against hemagglutinin
  18. Natural Products as Mcl-1 Inhibitors: A Comparative Study of Experimental and Computational Modelling Data
  19. An improved method for synthesis of non-symmetric triarylpyridines
  20. Natural Products as Mcl-1 Inhibitors: A Comparative Study of Experimental and Computational Modelling Data
  21. (1R,2R,3S,4R)-1-(Acetylamino)-2,4,5-tris(acetyloxy)-1-((2S)-4-(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl)pentan-3-yl Acetate
  22. Exploring the Galectin Network by Light and Fluorescence Microscopy
  23. Carbohydrate Chemistry: Critical for our Future
  24. Cyclisations and Strategies for Stereoselective Synthesis of Piperidine Iminosugars
  25. What is the Sugar Code?
  26. 1-Tosyl-6-vinyl-4,5,6,7-tetrahydro-1H-benzo [d] imidazole-2-amine
  27. Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells
  28. Imitating evolution’s tinkering by protein engineering reveals extension of human galectin-7 activity
  29. Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen
  30. Development of Mcl-1 inhibitors for cancer therapy
  31. Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes
  32. Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis
  33. Migrastatin analogues with an (E)-alkene at the ring C-3: synthesis, conformational analysis and biological evaluation
  34. Correction to: Influence of protein (human galectin-3) design on aspects of lectin activity
  35. (2S,3R,6R)-2-[(R)-1-Hydroxyallyl]-4,4-dimethoxy-6-methyltetrahydro-2H-pyran-3-ol
  36. Influence of protein (human galectin-3) design on aspects of lectin activity
  37. Cover Feature: A Route to 1‐Deoxynojirimycin and 1‐Deoxymannojirimycin Derivatives with Quaternary Centers Adjacent to the Ring Nitrogen from Methyl α‐d‐Mannopyranoside (Eur. J. Org. Chem. 16/2020)
  38. A Route to 1‐Deoxynojirimycin and 1‐Deoxymannojirimycin Derivatives with Quaternary Centers Adjacent to the Ring Nitrogen from Methyl α‐d‐Mannopyranoside
  39. Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin1 binding
  40. Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity
  41. Synthesis and biological evaluation of S-simplexides and other analogues of simplexide
  42. Microcavity-Supported Lipid Membranes: Versatile Platforms for Building Asymmetric Lipid Bilayers and for Protein Recognition
  43. How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1
  44. N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
  45. Ligand design for somatostatin receptor isoforms 4 and 5
  46. Lewis acid promoted anomerisation of alkyl O- and S-xylo-, arabino- and fucopyranosides
  47. Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents
  48. Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation
  49. Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
  50. Stereoselective Epimerizations of Glycosyl Thiols
  51. Carbohydrate Chemistry
  52. Allylic Azide Rearrangement in Tandem with Intramolecular Huisgen Cycloaddition for Iminosugar and Glycomimetic Synthesis: Functionalized Piperidine, Pyrrolidine, and Pyrrolotriazoles from d-Mannose
  53. Methyl 2,3,6-tri-O-Benzoyl-4-O-(tert-butyldimethylsilyl)-β-d-galactopyranoside
  54. Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea
  55. Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
  56. Synthesis and Biological Evaluation of Migrastatin Macrotriazoles
  57. Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene froml-Sorbose
  58. Multivalent Carbohydrate-Lectin Interactions: How Synthetic Chemistry Enables Insights into Nanometric Recognition
  59. Coiled coil type neoglycoproteins presenting three lactose residues
  60. Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of α-Se-GalCer
  61. Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars
  62. Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
  63. Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring
  64. Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity
  65. Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity
  66. Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor
  67. Lectins: Getting Familiar with Translators of the Sugar Code
  68. Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
  69. Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E‐Cadherin Dynamics
  70. Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)
  71. Synthesis of α-galactosyl ceramide analogues with an α-triazole at the anomeric carbon
  72. Synthesis of iminosugar derivatives presenting naphthyl and alkyl amine interacting groups and binding to somatostatin receptors
  73. Migrastatin Analogues Inhibit Canine Mammary Cancer Cell Migration and Invasion
  74. Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl4
  75. Synthesis of a-O- and a-S-Glycosphingolipids Related to Sphingomonous cell Wall Antigens Using Anomerisation
  76. Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint
  77. The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity
  78. Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths
  79. Multivalent glycoconjugates as anti-pathogenic agents
  80. Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori
  81. Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
  82. Synthesis, kinase activity and molecular modeling of a resorcylic acid lactone incorporating an amide and a trans-enone in the macrocycle
  83. Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity
  84. Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons
  85. Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic
  86. Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions
  87. Synthesis of α-S-Glycosphingolipids Based on Uronic Acids
  88. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation
  89. Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold
  90. Towards echinomycin mimetics by grafting quinoxaline residues on glycophane scaffolds
  91. N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells
  92. Ultrasound-assisted synthesis of C-glycosides
  93. Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination
  94. Synthesis of congeners of migrastatin and dorrigocin A from d-xylose
  95. SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher α:β Anomer Ratios and Reaction Rates
  96. Metathesis and Macrocycles with Embedded Carbohydrates
  97. Biological study of the Angiogenesis Inhibitor N‐(8‐(3‐ethynylphenoxy)octyl‐1‐deoxynojirimycin
  98. Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins
  99. Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from l-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition
  100. Glycotriazolophane Synthesis via Click Chemistry
  101. α-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives
  102. Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework
  103. Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
  104. Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis
  105. New Access to 1-Deoxynojirimycin Derivatives via Azide−Alkene Cycloaddition
  106. Synthesis of Somatostatin Mimetics Based on 1‐Deoxynojirimycin
  107. Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis
  108. Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D‐Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener Is a Potent Inhibitor of Gastric Cancer Cell Migration
  109. Corrigendum to “Synthesis of sugar-lactams from azides of glucuronic acid”
  110. Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles
  111. Synthesis of Novel Migrastatin and Dorrigocin A Analogues from D‐Glucal
  112. Synthesis of sugar-lactams from azides of glucuronic acid
  113. Peptidomimetics, Glycomimetics and Scaffolds from Carbohydrate Building Blocks
  114. Selective protecting group manipulations on the 1-deoxynojirimycin scaffold
  115. Synthesis of Macrolide−Saccharide Hybrids by Ring-Closing Metathesis of Precursors Derived from Glycitols and Benzoic Acids
  116. Glycosidation–Anomerisation Reactions of 6,1‐Anhydroglucopyranuronic Acid and Anomerisation of β‐D‐Glucopyranosiduronic Acids Promoted by SnCl4
  117. The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions
  118. Syntheses of Peptidomimetics Based on Pyranose and Polyhydroxylated Piperidine Scaffolds
  119. N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types
  120. N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF—A significant increase in potency using per-O-acetylated sugar analogues
  121. Symbiosis in chemistry and biology
  122. On the Mechanism of Mitochondrial Uncoupling Protein 1 Function
  123. Synthesis of Somatostatin Mimetics Based on the 1-Deoxymannojirimycin Scaffold
  124. Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins
  125. Novel Synthesis of Castanospermine and 1-Epicastanospermine
  126. The crystal structure of a cyclic glycolipid reveals a carbohydrate–carbohydrate interaction interface
  127. Synthesis and Structural Analysis of the Anilides of Glucuronic Acid and Orientation of the Groups on the Carbohydrate Scaffolding
  128. Synthesis of Structurally Defined Scaffolds for Bivalent Ligand Display Based on Glucuronic Acid Anilides. The Degree of Tertiary Amide Isomerism and Folding Depends on the Configuration of a Glycosyl Azide
  129. A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors
  130. Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic
  131. Synthesis of Structurally Diverse and Defined Bivalent Mannosides on Saccharide Scaffolding
  132. Metathesis of Structurally Preorganized Bivalent Carbohydrates. Synthesis of Macrocyclic and Oligomeric Scaffolds
  133. Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2
  134. Conformational Effects on Glycoside Reactivity:  Study of the High Reactive Conformer of Glucose
  135. Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth
  136. Synthesis of peptidomimetics based on iminosugar and β-d-glucopyranoside scaffolds and inhibiton of HIV-protease
  137. Glycosidation Reactions of Silyl Ethers with Conformationally Inverted Donors Derived from Glucuronic Acid: Stereoselective Synthesis of Glycosides and 2‐Deoxyglycosides
  138. A General Synthesis of Iminosugars
  139. Synthesis of an iminosugar based peptidomimetic analogue
  140. Synthesis and X-ray single crystal structure of a bivalent glycocluster
  141. Development of Carbohydrate-Based Scaffolds for Restricted Presentation of Recognition Groups. Extension to Divalent Ligands and Implications for the Structure of Dimerized Receptors
  142. Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
  143. Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone
  144. Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library
  145. Synthesis of α-Glucuronic Acid and Amide Derivatives in the Presence of a Participating 2-Acyl Protecting Group
  146. Structure-based design and synthesis of HIV-1 protease inhibitors employing β-d-mannopyranoside scaffolds
  147. A Study of the Epoxidation of 6-Deoxyhex-5-enopyranosides. 1,5-Dicarbonyl Derivatives and Novel Synthetic Routes to d-xylo-Hexos-5-ulose and d-lyxo-Hexos-5-ulose
  148. A New Route toexo-Glycals Using the Ramberg−Bäcklund Rearrangement
  149. Novel Synthesis of the Glycosidase Inhibitor Deoxymannojirimycin and of a Synthetic Precursor d-lyxo-Hexos-5-ulose
  150. Stereospecific synthesis of β-d-allopyranosides by dihydroxylation of β-d-erythro-2,3-dideoxyhex-2-enopyranosides
  151. Application of Ugi Reactions in Synthesis of Divalent Neoglycoconjugates:  Evidence That the Sugars Are Presented in Restricted Conformation
  152. Synthesis of d-Hexos-5-uloses by Novel in Situ Hydrolysis of Epoxides Derived from 6-Deoxyhex-5-enopyranosides
  153. The reactions of diazo compounds with lactones. Part 2.† The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation
  154. The reactions of diazo compounds with lactones. Part 1. Cyclopropanespiro-β-lactones from diketene: synthesis and reactions
  155. The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewisx
  156. A Ramberg-Bäcklund approach to exo-glycals
  157. The synthesis of novel structural analogues of sialyl Lewisx
  158. Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-β-l-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-β-d-xylopyranosyl chloride
  159. Metal catalysed rearrangement of cyclopropanespiro-β-lactones to 2-furanones
  160. Lewis acid promoted anomerisation: recent developments and applications