What is it about?

Precision nutrition has great potential to offer multidimensional and dynamic nutrition recommendations. We have shown that a designer protein-deprived diet enriched in free essential amino acids can i) promote the brown fat thermogenic program and fatty acid oxidation, ii) stimulate uncoupling protein 1 (UCP1)-independent respiration in subcutaneous white fat, iii) change the gut microbiota composition, and iv) prevent and reverse obesity and dysregulated glucose homeostasis in multiple mouse models, prolonging the healthy lifespan.

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Why is it important?

Our results suggest that brown and white fat may be targets of specific amino acids to control UCP1-dependent and -independent thermogenesis, thereby contributing to the improvement of metabolic health.


If extended to humans, such dietary manipulation could potentially have a positive impact on metabolic health favouring the prevention and treatment of obesity and type 2 diabetes regardless of calorie consumption.

Enzo Nisoli
Universita degli Studi di Milano

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This page is a summary of: Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis, Diabetes, August 2020, American Diabetes Association,
DOI: 10.2337/db20-0489.
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