What is it about?
Each of us has unique DNA sequences. Identifying which of these sequences underlie the risk for developing kidney disease has become a major area of study. This paper reviews the strengths and weaknesses of using genes to guide drug discovery in diabetic kidney disease.
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Why is it important?
Diabetic kidney disease is main cause of kidney failure requiring dialysis and the major risk for death in diabetic patients however there are only two known treatments that only partially reduce this risk. The new access to genetic sequence information offers hope for identifying new treatments.
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This page is a summary of: The Use of Genomics to Drive Kidney Disease Drug Discovery and Development, Clinical Journal of the American Society of Nephrology, March 2020, American Society of Nephrology,
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