Maternal SVP exposure has a detrimental impact on pups during the perinatal period.

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The maternal administration of SVP stimulated the maternal/neonatal stress-brain (HPA) axis. Also, SVP perturbed the production of neonatal adipocytokines triggering the oxidative stress state. A novel interpretation of the results of this study is that the maternal SVP might act as a neonatal oxido-inflammatory and neuroendocrine-cytokines disruptor resulting in multiple adverse actions on neonates during the perinatal period (Figure 3). Based on the results of this study, the HPA axis should be evaluated during and shortly after AEDs (SVP) exposure, as disruption of the responses of the maternal HPA axis can have severe long-term consequences for neonates, particularly the developing brain. Further investigations are required to verify the current data with human health and to determine the precise mechanisms of these disruptions.

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