What is it about?

Weight gain induced Insulin Resistance leads to compensatory Insulin hypersecretion. So obese Type 2 Diabetes patients have increased fasting insulin levels. But non-obese Indians suffering from Type 2 Diabetes have been reported to have low levels of insulin. We tested whether the phenomenon of insulin hypersecretion holds true for non-obese Indians.

Featured Image

Why is it important?

Our findings provides the possibility that Type 2 Diabetes in non-obese people has a different pathology than the classically known Type 2 Diabetes. This is important from the aspect of screening and even therapy for non-obese patients.


Our report supports the possibility of Type 2 Diabetes to have a different natural history in non-obese Indians. This possibility calls for a different screening criteria in non-obese Indians and also asks for further research towards developing new therapy options for this group.

Dr Jit Sarkar
CSIR-Indian Institute of Chemical Biology

Read the Original

This page is a summary of: Impaired compensatory hyperinsulinemia among nonobese type 2 diabetes patients: a cross-sectional study, Therapeutic Advances in Endocrinology and Metabolism, January 2019, SAGE Publications, DOI: 10.1177/2042018819889024.
You can read the full text:




The following have contributed to this page