What is it about?

The posterior perforated substance can serve as a landmark for surgical operations in the adjacent regions of the midbrain and the vessels passing through it. Moreover, the posterior perforated substance contains the interpeduncular nucleus responsible for the mental state of the individual, various addictions and psychiatric conditions.

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Why is it important?

The posterior perforated substance area is of great interest for surgical interventions. Future studies of the interpeduncular nucleus anticipate the development of drugs to affect different types of dependencies and some mental diseases.

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This page is a summary of: The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma, Current Topics in Medicinal Chemistry, January 2020, Bentham Science Publishers, DOI: 10.2174/1568026619666191127122452.
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