What is it about?
This article is about the different types of proteins that pump drug molecules and other potentially harmful compounds out of bacterial cells, which are known as multidrug efflux pumps. These proteins are a major mechanism of antibiotic resistance. Study of the structures, functions and molecular mechanisms of multidrug efflux pumps is important for understanding this cause of antibiotic resistance and for developing drugs or other strategies to combat antibiotic resistance.
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Why is it important?
Antibiotic resistance is a global problem for which rates are dramatically increasing and the mechanisms of resistance are varied and complicated. Development of multidrug-resistant bacteria is of high concern, especially given the slow progress in creating new antibiotics, and this is one of the most important public health threats of the 21st century. Studying the mechanisms of antibiotic resistance is therefore highly important.
Read the Original
This page is a summary of: Bacterial Multidrug Efflux Proteins: A Major Mechanism of Antimicrobial Resistance, Current Drug Targets, April 2018, Bentham Science Publishers, DOI: 10.2174/1389450119666180426103300.
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