What is it about?

This review report how dendrogenin A was discovered and described its first in vitro and in vivo biological and pharmacological properties

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Why is it important?

cholesterol is generally considered as causative of cancers although epidemiological studies are not conclusive in most cases and is linked to the occurence of neurodegenerative diseases. The identification of a cholesterol metabolite displaying tumor suppressive properties mitigate this assumption for cancers and opens up new fields of investigations in the etiology of these diseases .


The use of Dendrogenin A in the chemoprevention and the treatment of cancer and neurodegenerative diseases deserves further investigations.

Dr Marc Etienne Poirot
Cancer Research Center of Toulouse UMR 1037 Inserm-university of Toulouse, France

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This page is a summary of: Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties, Current Medicinal Chemistry, October 2015, Bentham Science Publishers,
DOI: 10.2174/0929867322666150716114912.
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