What is it about?

This article builds on our previous published work where we showed that a long surface structure of Group A Streptococcus (known as a pilus) can be produced on the surface of the harmless bacterium Lactococcus lactis. These bacteria were used to vaccinate mice which become immune against bacterial infection.

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Why is it important?

The work describes a novel vaccine candidate against group A Streptococcus which causes a range of diseases in humans, including skin and soft tissue infections, toxic shock and rheumatic fever.

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This page is a summary of: Expanding strain coverage of a group A Streptococcus pilus–expressing Lactococcus lactis mucosal vaccine, Immunology and Cell Biology, April 2023, Wiley, DOI: 10.1111/imcb.12643.
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