CPAP-therapy and arterial stiffness in arterial hypertension patients

What is it about?

The idea of the study was to understand the effects of CPAP therapy on arterial stiffness, central BP, and reflected pulse wave characteristics in patients with severe OSA and arterial hypertension. We concluded that 3 weeks of effective CPAP therapy results in significant additional decrease in blood pressure (office and ambulatory) and improvement in arterial stiffness parameters.

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Why is it important?

In the study we had cross-over design with placebo CPAP-therapy control. All patients received standardized antihypertensive treatment (consisting of valsartan 160 mg + amlodipine 5–10 mg + hydrochlorothiazide 25 mg). With this design we showed additional effect of CPAP therapy on blood pressure and arterial stiffness parameters.