What is it about?
Extrapulmonary high grade neuroendocrine rectal carcinomas (HGNEC) are very rare, aggressive and almost always metastatic at presentation. These features entail that an accurate diagnosis should be as rapid as possible for the best management of the patient. We describe for the first time the use of pCLE as a powerful technique in a HGNEC patient, showing that pCLE represents a valid and helpful method for in vivo prompt and accurate diagnosis.
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Why is it important?
Our findings show the diagnostic efficacy of pCLE technique that can be performed during a standard endoscopic examination. This is valid above all when a prompt diagnosis is needed
Perspectives
I think that the innovative pCLE approach can really improve the diagnostic accuracy and accomplish an optimal clinical management of HGNEC patients. Obviously, to become solid and highly accurate, this technique should be performed on a group of HGNEC patients. In the absence of other cases enrolled in this study since this type of tumor is extremely rare above all in rectum, at the moment we only suggest some pCLE criteria for the HGNEC evaluation. These deal with the presence of a huge amount of small cells and a highly altered vasculature
PhD Paola Spessotto
Centro di Riferimento Oncologico
Read the Original
This page is a summary of: Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation, OncoTargets and Therapy, June 2019, Dove Medical Press,
DOI: 10.2147/ott.s198034.
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