What is it about?

Prospective, randomised trial comparing short and long time-interval between preoperative radiotherapy 5x5 Gy and surgery. Short-course preoperative radiotherapy and delayed surgery may be associated with increased risk of local recurrence.

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Why is it important?

Optimal time-interval between 5x5 Gy radiotherapy and surgery has not been unequivocally established so far. The study adds to the current knowledge on this topic showing similar overall and disease-free survival but increased risk of local recurrence in individuals operated on 4-5 weeks after the end of radiotherapy.

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This page is a summary of: Preoperative radiotherapy 5 × 5 Gy and short versus long interval between surgery for resectable rectal cancer: 10-Year follow-up of the randomised controlled trial, Radiotherapy and Oncology, November 2021, Elsevier, DOI: 10.1016/j.radonc.2021.10.006.
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