What is it about?
The aim of this study was to evaluate if there is a relationship between the two pro-inflammatory polymorphisms (TNF-α-1031T/C and IL-1β-511C/T) and the anti-inflammatory polymorphism IL-10-1082G/A and PVL risk in Brazilian newborns with and without this injury.
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Why is it important?
There is evidence of an association between the polymorphisms TNF-α-1031T/C, IL-1β-511C/T, and IL-10-1082G/A and PVL risk in this studied Brazilian newborns population.
Perspectives
Such knowledge may enhance the understanding of the pathophysiology of this disorder and facilitate the discovery of the molecular causes of PVL, providing new perspectives on its early diagnosis and stimulating new research. The genetic association with PVL strengthens the pro-inflammatory polymorphisms TNF-α -1031T/C and IL-1β -511C/T and the anti-inflammatory polymorphism IL-10 -1082 G/A hypothesis with regard to PVL pathogenesis.
PROF DR VANIA PIATTO
FAMERP
Read the Original
This page is a summary of: The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy, Journal of Inflammation Research, May 2016, Dove Medical Press,
DOI: 10.2147/jir.s103697.
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