What is it about?

Inflammation is seen as a driver for Alzheimer's Disease. In this study we identified that novel markers of inflammation, such as Adenosine Deaminase, which is responsible for sleep regulation, are predictive of the likelihood of Alzheimer's in a clinical population.

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Why is it important?

Our study found increased levels of specific markers of inflammation in Alzheimer's Disease. These markers may in future help identify which patients are at most risk of progression to Alzheimer's. Further validation is required to assess the prognostic efficacy of these inflammation markers when used in conjunction with established measures of Alzheimer's Disease.


This article was a great opportunity to work with an interdisciplinary group of academics and clinicians working across immunology, neurology and data science. Our ultimate aim is to enhance the diagnosis of dementia. With our different perspectives, we worked towards evaluating the role of inflammation in dementia and identified a novel marker relating to sleep regulation which is predictive of the likelihood of Alzheimer's Disease. Our study was based on a heterogenous clinical cohort, showing potential for clinical translation of inflammation markers as prognostic tools in dementia.

sofia michopoulou
University Hospital Southampton NHS Foundation Trust

Read the Original

This page is a summary of: Biomarkers of Inflammation Increase with Tau and Neurodegeneration but not with Amyloid-β in a Heterogenous Clinical Cohort, Journal of Alzheimer s Disease, October 2022, IOS Press,
DOI: 10.3233/jad-220523.
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