Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist

Masoud Ghorbani, Shahram Teimourian, Reza Farzad, Nabiollah Namvar Asl
  • Drug Design Development and Therapy, February 2015, Dove Medical Press
  • DOI: 10.2147/dddt.s73891

Histological changes of adipocytes after treatment with CL 316,243

What is it about?

The objective of this experiment was to study the effect of CL 316,243 (CL) (a highly selective β3-adrenergic receptor agonist) on cellular changes occurring in retroperitoneal white adipose tissue (RWAT) of lean and obese rats.

Why is it important?

Development of thermogenic drugs for the treatment of obesity has now focused on selective β3-adrenergic agonists. It has been postulated that thermogenic drugs might stimulate thermogenesis in BAT and induce lipolysis of WAT.


Dr Masoud Ghorbani
Pasteur Institute of Iran

Treatment of both lean and obese Zucker rats with CL induces extensive remodeling of RWAT that includes shrinkage of white adipose tissue, the appearance of abundant multilocular cells in RWAT together with the appearance of a marked increase of UCP, preferentially in lean rats.

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The following have contributed to this page: Dr Masoud Ghorbani and Dr Masoud Ghorbani