What is it about?

Population modelling is a growing mathematical technique that can be used to understand the kinetics of a drug. This can then help with the design of studies by determining the best time to take samples and how many subjects to include. The paper discusses the use of this technique in two oral solution pediatric trials and how the data could then be used to determine the best doses to use in an efficacy trial.

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Why is it important?

Treating children with analgesic medication is difficult as there are very few drug that have been licenced for use in children and medication is often used off-label. Tapentadol is the first strong analgesic to have been tested in children aged birth to <18 years of age, with the aim of finding the best dose to use in each age group.

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This page is a summary of: Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population, Journal of Pain Research, October 2019, Taylor & Francis,
DOI: 10.2147/jpr.s208454.
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