What is it about?

We reported 2 cases with positive pancreatic autoantibodies, accompanied by Hashimoto's disease, and the observation of the progression to Latent autoimmune diabetes in adults (LADA), a special subtype of type 1 diabetes in adults. The study will discuss the possible connection of autoimmune background in thyroid disease and its relationship with diabetes.

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Why is it important?

The GAD autoimmune antibodies are generally associated with autoimmune diabetes and stiff-man syndrome. Its positive can be also observed in thyroid disease. Will this connection have a common etiology, and what will we implement to early prevent the patients from progressing to the LADA, just an immunosuppression approach?


After follow-up in 3 years, we found these two patients neither developed into LADA, and one of the female patients returned to normal glycemia in 3rd year after bodyweight management, for her insulin-related indices approximate to the IGT and IFG due to loss of diet control.

Dr. Song Wen
Shanghai Pudong Hospital

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This page is a summary of: Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series, Diabetes Metabolic Syndrome and Obesity, March 2021, Taylor & Francis, DOI: 10.2147/dmso.s295847.
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