What is it about?
Our work synthesized a group of compounds and evaluated their anti-tumor activities virtually and then in vitro. The results indicated that the new tolfenamic acid derivatives are promising chemotherapeutics by targeting blood vessel formation which induced cancer cell death.
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Why is it important?
Current chemotherapy drugs are non-selective with numerous side effects. Tumor growth and spread (metastasis) depends on the formation of blood vessels (angiogenesis). Our novel tolfenamic acid derivatives target this process by inhibiting the action of a major receptor VEGFR.
Perspectives
The increasing incidence of cancer worldwide, along with the appearance of malignancies that show resistance to traditional anti-tumor treatments, has resulted in huge loss in human life. Nowadays, there are great efforts focusing on maximizing chemotherapy treatment efficiency, minimizing the side effects, and identifying new drugs which might work through signaling pathways that differ from what regular drugs use to overcome drug resistance. For several years, my collaborators and I have been working on developing new anti-cancer drugs that target processes upregulated in cancer cells such as proliferation and survival.
Lubna Tahtamouni
Colorado State University System
Read the Original
This page is a summary of: Synthesis, Molecular Docking Studies, and In vitro Anticancer Evaluation
of Novel Tolfenamic Acid Derivatives, Letters in Drug Design & Discovery, September 2023, Bentham Science Publishers, DOI: 10.2174/1570180819666220831110423.
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