What is it about?
Our work synthesized a group of compounds and evaluated their anti-tumor activities virtually and then in vitro. The results indicated that the new tolfenamic acid derivatives are promising chemotherapeutics by targeting blood vessel formation which induced cancer cell death.
Photo by Hush Naidoo Jade Photography on Unsplash
Why is it important?
Current chemotherapy drugs are non-selective with numerous side effects. Tumor growth and spread (metastasis) depends on the formation of blood vessels (angiogenesis). Our novel tolfenamic acid derivatives target this process by inhibiting the action of a major receptor VEGFR.
Read the Original
This page is a summary of: Synthesis, Molecular Docking Studies, and In vitro Anticancer Evaluation
of Novel Tolfenamic Acid Derivatives, Letters in Drug Design & Discovery, September 2023, Bentham Science Publishers, DOI: 10.2174/1570180819666220831110423.
You can read the full text:
The following have contributed to this page