What is it about?
Chronic ethanol consumption is a risk factor for colorectal cancer. We indicated to result in an alteration of mouse fecal microbiota structures, and this appeared to be consistent with the proposed sustained generation of oxidative stress in the colonic environment during chronic ethanol consumption.
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Why is it important?
We indicated that the first experimental evidence that chronic ethanol administration results in elevated levels of advanced glycation end products (AGEs) and their receptors (RAGE) in the colonic tissues in mice is also shown, implying enhanced RAGE-mediated signaling with chronic ethanol administration.
Perspectives
I hope that researchers will consider this paper to be an area spread human evidence, and that it will be connected preventive medicine fields progress.
Hideo Ohira
Kobe Gakuin Daigaku
Read the Original
This page is a summary of: Alteration of oxidative-stress and related marker levels in mouse colonic tissues and fecal microbiota structures with chronic ethanol administration: Implications for the pathogenesis of ethanol-related colorectal cancer, PLoS ONE, February 2021, PLOS,
DOI: 10.1371/journal.pone.0246580.
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