What is it about?
On infecting a red blood cell, the human malaria parasite indulges in its selective modification by expressing proteins and trafficking to various destinations. This paper identifies such a class of parasite proteins and explores the mechanism for their targeting.
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Why is it important?
The findings from this paper defines a unique mechanism engaged by the human malaria parasite to actively modify the host red blood cells and to aid in its survival and pathogenesis.
Perspectives
The emergence of drug resistance in human malaria is alarming., which necessitates exploring and finding alternate drug targets for therapeutic intervention. I am really happy with the outcome from this research and the article. Although some readers might find it to be too long, I hope that as they read it, they will enjoy the step by step approach that we took to ultimately unravel the trafficking puzzle in malaria infected red blood cells. I will greatly appreciate any suggestions.
Souvik Bhattacharjee
Jawaharlal Nehru University
Read the Original
This page is a summary of: A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum, PLoS Pathogens, November 2021, PLOS,
DOI: 10.1371/journal.ppat.1009595.
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