What is it about?

The Chikungunya virus can cause severe illness, including fever and joint pain, and affects many people around the world. In this study, we used a systems biology approach to understand how the virus affects the body at the molecular level. By analyzing the blood of infected patients, we identified genes that could be targeted for new treatments. Our findings provide valuable insights into the early stages of the infection and could lead to the development of more effective therapies.

Featured Image

Why is it important?

This work on the Chikungunya virus is important because it sheds light on the molecular mechanisms involved in the infection, which can inform the development of new treatments. This is especially relevant given the significant public health impact of this virus on millions of people around the world. What is unique about this study is its use of a systems biology approach to analyze the blood transcriptomes of infected patients, allowing for a detailed understanding of the molecular events induced by the infection. The identification of genes that could serve as therapeutic targets for the disease is also noteworthy.


This research is timely given the ongoing threat of the Chikungunya virus, and the need for effective therapies to combat its impact on public health. By providing insights into the early stages of the infection, this study could inspire further research and development of new treatments, ultimately making a significant difference in the lives of those affected by the virus.

Helder Nakaya
Hospital Israelita Albert Einstein

Read the Original

This page is a summary of: Systems analysis of subjects acutely infected with the Chikungunya virus, PLoS Pathogens, June 2019, PLOS,
DOI: 10.1371/journal.ppat.1007880.
You can read the full text:

Open access logo


The following have contributed to this page