A compound from Chinese vinegar shows promise in fighting disease through glycan biosynthesis.

What is it about?

Our study investigates the effect of an antioxidant compound, 5-hydroxy-4-phenyl-butenolide (5H4PB), found in Chinese aromatic vinegar, on glycan biosynthesis in human keratinocyte cells. The study also explores the use of GlycoMaple, a tool that predicts glycan structures based on gene expression data, to understand changes in glycan structure in response to changes in gene expression. The results suggest that an increase in core fucose may be a novel marker of oxidative stress response and that agents that activate the antioxidant response may affect glycan biosynthesis.

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Photo by CA Creative on Unsplash

Photo by CA Creative on Unsplash

Why is it important?

Our study highlights the complex relationship between glycan biosynthesis and oxidative stress and provides a potential new marker of oxidative stress response. It also sheds light on the potential health benefits of the compound 5H4PB found in Chinese aromatic vinegar and the potential of GlycoMaple as a tool for predicting glycan structures in response to changes in gene expression. These findings may have implications for the development of treatments for various pathological conditions associated with oxidative stress, such as Alzheimer's disease and cardiovascular disease.

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