What is it about?

Our study investigates the effect of an antioxidant compound, 5-hydroxy-4-phenyl-butenolide (5H4PB), found in Chinese aromatic vinegar, on glycan biosynthesis in human keratinocyte cells. The study also explores the use of GlycoMaple, a tool that predicts glycan structures based on gene expression data, to understand changes in glycan structure in response to changes in gene expression. The results suggest that an increase in core fucose may be a novel marker of oxidative stress response and that agents that activate the antioxidant response may affect glycan biosynthesis.

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Why is it important?

Our study highlights the complex relationship between glycan biosynthesis and oxidative stress and provides a potential new marker of oxidative stress response. It also sheds light on the potential health benefits of the compound 5H4PB found in Chinese aromatic vinegar and the potential of GlycoMaple as a tool for predicting glycan structures in response to changes in gene expression. These findings may have implications for the development of treatments for various pathological conditions associated with oxidative stress, such as Alzheimer's disease and cardiovascular disease.


The results of this study provide a new perspective on the potential role of Chinese vinegar-derived compounds in promoting antioxidant response and affecting glycan biosynthesis, highlighting the importance of understanding the interplay between these processes in the context of oxidative stress. The development of tools such as GlycoMaple can further aid in the prediction of glycan structures and potentially lead to the identification of new biomarkers of oxidative stress response.

Ayano Satoh, PhD
Okayama University

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This page is a summary of: Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response, PLoS ONE, February 2023, PLOS,
DOI: 10.1371/journal.pone.0281516.
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