What is it about?

The go-to clinical process for surgical planning in epilepsy is through an invasive procedure called intracranial electroencephalography, involving drilling holes in the skull or removing a part of the skull, and lasting multiple days. In this work, we discovered that fast oscillations in scalp-recorded electroencephalography can pinpoint brain tissues responsible for epileptic seizures.

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Why is it important?

Our findings show that high frequency oscillations riding epileptiform spikes provide an accurate biomarker to identify, delineate and localize where epileptic seizures originate. Its establishment may change clinical practice in the future to manage drug-resistant epilepsy.

Perspectives

I hope this article illustrates the values and merits of noninvasive neurotechnology, which is completely safe and noninvasive. I hope the work would benefit many epilepsy patients down the road.

Dr. Bin He
Carnegie Mellon University

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This page is a summary of: Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources, Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2011130118.
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