What is it about?

Globally, TB is the leading cause of infectious disease morbidity and mortality with many diagnostic uncertainties. Access to affordable and rapid diagnostics remained a major challenge for many developing countries which bear the greatest burden of TB delaying the initiation time to treatment.

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Why is it important?

The proportion of RR-TB we observed in this study was high. A higher proportion of RR TB was detected outside of the RRDR. Neverthless, a significant number of the GeneXpert MTB/RIF Assay probes were identified as unhybridized and this critical observation would mean that most of the probes had no or minimal utility in this geographical region.


further studies to uncover mutation in the rpoB gene conferring RR and reshape TB triage and definite diagnostic algorithm in Ethiopia.

Gizachew Taddesse AKALU

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This page is a summary of: High proportion of RR-TB and mutations conferring RR outside of the RRDR of the rpoB gene detected in GeneXpert MTB/RIF assay positive pulmonary tuberculosis cases, in Addis Ababa, Ethiopia, PLoS ONE, December 2022, PLOS, DOI: 10.1371/journal.pone.0277145.
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