What is it about?

Vasospastic angina (VSA) is a benign disorder, but sometimes leads to acute coronary syndrome and life-threatening ventricular arrhythmias. Patients resuscitated from sudden cardiac arrest (SCA) due to VSA are at a high risk of recurrent lethal arrhythmia. However, the effects of Implantable cardioverter-defibrillator (ICD) implantation on these patients remain inconclusive. We showed there was no significant difference in the incidence of the primary endpoint (a composite of all-cause death and appropriate ICD therapy) between patients with (n=51) and without (n=229) VSA during a median follow-up period of 3.8 years (24% vs. 33%, p = 0.19).

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Why is it important?

Long-term clinical outcomes were not different between patients with and without VSA. ICD therapy may be considered in patients with VSA and those with other etiologies after resuscitation from SCA.


This study was not a randomized controlled trial, and clinical outcomes in patients with VSA and SCA were evaluated in a limited cohort of patients who received ICD implantation as secondary prophylaxis. Therefore, this study did not directly address the effectiveness of ICD in patients with VSA, and further randomized controlled trial will be needed to address this issue.

Chiba Daigaku

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This page is a summary of: Implantable cardioverter-defibrillator therapy after resuscitation from cardiac arrest in vasospastic angina: A retrospective study, PLoS ONE, October 2022, PLOS,
DOI: 10.1371/journal.pone.0277034.
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