What is it about?

We have derived two simplified two-variable nonlinear pacemaker cell models from popular Aliev-Panfilov and Corrado-modified Mitchell-Schaeffer cardiac excitable models and considered their single-cell and coupled dynamic properties. As application examples of combined pacemaker-excitable systems, we have demonstrated the results of simulations of the 2D sinoatrial node and 3D intestine tissue (including animation video).

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Why is it important?

The development of patient-specific medicine and medical device testing requiring real-time computer simulations is of great interest. Such applications are usually based on simplified mathematical models of cells. The considered pacemaker variants of the Aliev-Panfilov and modified Mitchell-Schaeffer models can be used for computationally efficient electrophysiological modeling of tissues that include primary and subsidiary pacemaking cells, allowing the development of models for whole organs and various species.


The unified formulation for the conventional excitable cell models and proposed pacemaker models allows a convenient and easy implementation for the construction of personalized physiological models, inverse tissue modeling, and the development of real-time simulation systems for various organs that contain both pacemaker and excitable cells.

Prof. Maxim Ryzhii
University of Aizu

Read the Original

This page is a summary of: Pacemaking function of two simplified cell models, PLoS ONE, April 2022, PLOS, DOI: 10.1371/journal.pone.0257935.
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