What is it about?
We have derived two simplified two-variable nonlinear pacemaker cell models from popular Aliev-Panfilov and Corrado-modified Mitchell-Schaeffer cardiac excitable models and considered their single-cell and coupled dynamic properties. As application examples of combined pacemaker-excitable systems, we have demonstrated the results of simulations of the 2D sinoatrial node and 3D intestine tissue (including animation video).
Photo by Jair Lázaro on Unsplash
Why is it important?
The development of patient-specific medicine and medical device testing requiring real-time computer simulations is of great interest. Such applications are usually based on simplified mathematical models of cells. The considered pacemaker variants of the Aliev-Panfilov and modified Mitchell-Schaeffer models can be used for computationally efficient electrophysiological modeling of tissues that include primary and subsidiary pacemaking cells, allowing the development of models for whole organs and various species.
Read the Original
This page is a summary of: Pacemaking function of two simplified cell models, PLoS ONE, April 2022, PLOS, DOI: 10.1371/journal.pone.0257935.
You can read the full text:
The following have contributed to this page