What is it about?
The protection of chromosome ends by Telomeres is essential for human health and development. Telomere consists of proteins that specifically bind to the end. In some organisms such as the fruit fly Drosophila , this binding does not require an underlying DNA sequence. To learn more about this mode of telomere localization, we map Drosophila telomere-binding proteins in fine details. Our work has been greatly facilitated by the development of a new tool for the mapping of chromosomal proteins tagged with the GFP tag commonly used in biological research.
Photo by Edu Lauton on Unsplash
Why is it important?
We provided the most detailed distribution pattern of telomeric proteins which binding is sequence independent. Such an understanding is important because similar mechanisms might be employed by a significant fraction of tumor cells to escape the requirement for telomerase expression to achieve uncontrolled growth. In addition, the new genomic tool that we developed adds versatility to the existing mapping techniques.
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This page is a summary of: The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila, PLoS Genetics, September 2022, PLOS, DOI: 10.1371/journal.pgen.1010351.
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