What is it about?
The manuscript discusses non-specific binding of (undamaged) double-stranded DNA to a poxvirus uracil-DNA glycosylase.
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Why is it important?
The structure highlights protein-DNA interactions to non-specific undamaged double-stranded DNA and when compared to the structure of the specific complex with damaged uracil-containing DNA (Burmeister et al., 2015) it provides clues to structural transitions in lesion search of DNA repair enzymes.
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This page is a summary of: Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase, BMC Structural Biology, June 2015, Springer Science + Business Media,
DOI: 10.1186/s12900-015-0037-1.
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