What is it about?
HNK-102 is a newly synthesized oxime, found to be more effective compared to that of 2-PAM, as an antidote, against Nerve Agents poisoning in Swiss mice. In the recent past, we have reported its superiority over 2-PAM against Dichlorvos (an insecticide), DFP and frequently misused sarin (a nerve agent). The present study reports its better antidote action against tabun and soman (nerve agents).
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Why is it important?
Till date, no single oxime was found to be effective as antidote, against most of the nerve agents. For example, 2-PAM was not found to be effective against soman (a nerve agent) and dichlorvos (an insecticide) and HI-6 not effective against tabun poisoning. However, HNK-102 was found to be better antidote in terms of protection and also effective against all the above poisons in Swiss mice.
Perspectives
In real chemical warfare scenario, it is utmost important to administer appropriate antidote as quickly as possible to save the human life. However, there is no single oxime available for treatment of most of the nerve agents poisoning. It will be of no use to treat soman poisoning with 2-PAM or HI-6 used as antidote against tabun attack. Keeping this point in view we have synthesized and studied many molecules, and finally short listed HNK-102, an oxime. It has been found to be working more effectively as antidote against most of the nerve agents in Swiss mice. In other words, we have found out an oxime which is more effective as antidote against dichlorvos, DFP, sarin, tabun and soman.
Dr Pravin Kumar
Defence R&D Establishment
Read the Original
This page is a summary of: In vivo protection studies of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice, Human & Experimental Toxicology, January 2017, SAGE Publications,
DOI: 10.1177/0960327116685888.
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