What is it about?
A simple model shows that between study variation can be important when using historical controls. The TARGET study is used to illustrate this. Some implications for epidemiological studies are discussed. Recommendations for planning and reporting studies are made.
Photo by Ian Baldwin on Unsplash
Why is it important?
Researchers are encouraged to think about using historical data in a way that confronts the problems from the beginning. This should encourage more realistic approaches to using historical controls
Read the Original
This page is a summary of: Clustered allocation as a way of understanding historical controls: Components of variation and regulatory considerations, Statistical Methods in Medical Research, October 2019, SAGE Publications, DOI: 10.1177/0962280219880213.
You can read the full text:
The following have contributed to this page