What is it about?

We conducted a cross-sectional comparative study at Mansoura University Children’s Hospital, Egypt from 2014 to 2018 including 100 SLE children and 100 controls. We investigated both groups for VDR BsmI polymorphism using polymerase chain reaction. OS was assessed using malondialdehyde, glutathione S-transferase, superoxide dismutase, catalase and total antioxidant capacity.

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Why is it important?

The priority of this work for consideration of publication is to compare the genotypes and allelic frequencies of VDR BsmI polymorphism in Egyptian SLE patients and a control group and to describe the association between these genotypes and allelic frequencies and OS markers.


BB genotype frequency was found to be significantly higher in SLE group {p = 0.04, OR (95% CI) = 2.5 (1.01 – 5.9)}. However, VDR B allele and b allele showed insignificant differences between SLE patients and controls {p = 0.36, OR (95% CI) = 1.2 (0.8 – 1.8)}. Lower levels of glutathione S-transferase, superoxide dismutase and total antioxidant capacity were found in SLE group with statistically significant differences as regards glutathione S-transferase and superoxide dismutase (p < 0.001). Serum malondialdehyde and catalase levels were significantly higher in SLE group (p < 0.001). No significant differences were found between VDR BsmI polymorphism (genotypes and alleles) and OS markers in SLE group.

Assistant Professor Yahya Wahba
Mansoura University

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This page is a summary of: Oxidative stress and vitamin D receptor BsmI gene polymorphism in Egyptian children with systemic lupus erythematosus: a single center study, Lupus, May 2019, SAGE Publications, DOI: 10.1177/0961203319846380.
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