What is it about?

There are multiple insults to the male genital tract that have been associated with an increased risk of antisperm antibody formation. The most common of these is vasectomy. We prospectively investigated the incidence of antisperm antibodies in hydrocelectomized men and studied the effects of antisperm antibodies in semen characteristics.

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Why is it important?

The etiology of antibody formation in patients with a history of hydrocelectomy is uncertain. Disruption of the blood-testis barrier is believed to lead to exposure of sperm antigens to the immune system and production of antisperm antibodies.


This study indicates that patients with a history of hydrocelectomy may have an increased incidence of antisperm antibodies in sera. The increased incidence of antibodies we report appears to be clinically significant.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Antisperm antibodies in hydroceles before and after surgery, Fertility and Sterility, February 2003, Elsevier,
DOI: 10.1016/s0015-0282(02)04581-8.
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