What is it about?
Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice.
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Why is it important?
The present review focuses on the research evidence related to the therapeutic properties of bergapten collected in recent years. Many preclinical and in vitro studies have been evidenced the therapeutic action of BP; however, few clinical trials have been carried out to evaluate its efficacy.
Perspectives
In conclusion, although the use of BP has therapeutic applications on skin disorders as a sensitizing agent and as components of bergamot extract as hypolipemic therapy, more trials are necessary to define the doses and treatment guidelines and its usefulness against other pathologies such as cancer or bacterial infections.
habilitated doctor, chemist Monica BUTNARIU
University of Life Sciences "King Mihai I" from Timisoara
Read the Original
This page is a summary of: Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects, Oxidative Medicine and Cellular Longevity, April 2022, Hindawi Publishing Corporation,
DOI: 10.1155/2022/8615242.
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