What is it about?

The nuclear receptor Peroxisome Proliferator-activated Receptor is an important nuclear receptor in cells that plays a pivotal role in regulating fat metabolism and immune system. In this experiment we have attempted to activate such receptor to improve the immune system of the goats and the production of milk fat.

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Why is it important?

High producing dairy cows are known to have a weak immune system and fat in milk is the most valuable components; thus, the possibility of improving the immune system and increase the production of fat in milk are very attractive and important for the dairy industry


This was our first in vivo nutrigenomic experiment. The idea was very novel and exciting. Unfortunately the compound used turn out that did not activate the nuclear receptor; however, it improved the immune system. The latter is an important finding that open up the possibility for future research attempting to improve the immune system.

Massimo Bionaz
Oregon State University

Read the Original

This page is a summary of: 2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis, PPAR Research, January 2017, Hindawi Publishing Corporation,
DOI: 10.1155/2017/7097450.
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