What is it about?
Hyperosmolar induced cell death is an important issue as corneal epithelium is exposed to hyperosmolar stimulation in the common dry eye disease. We found that a ubiquitous protein, transglutaminase-2, is an important player in the hyperosmolar induced death in this context.
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Why is it important?
Transglutaminase-2 may form the basis of protective cell therapy in dry eye disease.
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This page is a summary of: Hyperosmolarity‐mediated mitochondrial dysfunction requires Transglutaminase‐2 in human Corneal epithelial cells, Journal of Cellular Physiology, December 2010, Wiley,
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