What is it about?

Hyperosmolar induced cell death is an important issue as corneal epithelium is exposed to hyperosmolar stimulation in the common dry eye disease. We found that a ubiquitous protein, transglutaminase-2, is an important player in the hyperosmolar induced death in this context.

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Why is it important?

Transglutaminase-2 may form the basis of protective cell therapy in dry eye disease.

Perspectives

Transglutaminase may regulate mitochondrial mediated cell death.

Prof Louis Tong
National University of Singapore

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This page is a summary of: Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human Corneal epithelial cells, Journal of Cellular Physiology, December 2010, Wiley, DOI: 10.1002/jcp.22389.
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