What is it about?
Prostaglandin E2 (PGE2) is an important lipid mediator in the alveoli. We have demonstrated that released PGE2 to alveolar lumen can be re-utilized in the interstitial tissue on the opposite side across the alveolar epithelium by being carried by prostaglandin transporters. This process does not involve PGE2 synthetic enzymes, therefore, PGE2 action may be regulated by transporters independent of the enzymes.
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Why is it important?
Since PGE2 serves as anti-fibrotic agent against pulmonary fibrosis. Since we have shown that fibrosis became more severe in Oatp2a1 (prostaglandin transporter)-deficient mice, our findings provide a rationale why the fibrosis could be exacerbated by impaired Oatp2a1 function. This provides a new insight for the pathophysiology of the lung fibrosis.
Perspectives
Pulmonary fibrosis leads to serious breathing problems, and the cause is often known. I hope this article showed how an important mediator PGE2 is regulated in the lungs, providing a hint how we could protect the lungs from fibrosis.
Takeo Nakanishi
Kanazawa Daigaku
Read the Original
This page is a summary of: Experimental Evidence for Resecretion of PGE2 across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport, Journal of Pharmacology and Experimental Therapeutics, November 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.118.249789.
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