What is it about?
The fate of [35S]-phenothiazine, a veterinary anthelmintic, has been investigated in the adult male marmoset (Callithrixjacchus) following oral administration. A near complete recovery of radioactivity (c.95%) was achieved in 0-3 days, with just over one-third of the dose (c.37%) being present in the urine and the remainder (c. 58%) being accounted for in the faeces. The majority of the urinary radioactivity (c. 91%) was present as conjugates, tentatively identified as phenothiazine glucuronide and leucophenothiazone sulphate. Smaller amounts of phenothiazone, thionol, phenothiazine sulphoxide and unchanged phenothiazine were also identified. The only compoundidentified in the faeces was unchanged phenothiazine.
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Why is it important?
First reports of the ADME of S-carboxymethyl-L-cysteine in the marmoset
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This page is a summary of: Metabolic Fate of Phenothiazine in the Marmoset (Callithrix jacchus), Drug Metabolism and Drug Interactions, January 2009, De Gruyter, DOI: 10.1515/dmdi.2009.24.2-4.137.
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