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It has been demonstrated that extracellular vesicles derived from endometrial mesenchymal stem cells (EV-endMSCs) exert an antioxidant effect and can be used as IVF coadjutants.

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The 20-80 μg/ml treatments decreased the expression of glutathione peroxidase (Gpx1), and the 10-40 μg/ml treatments reduced the expression of superoxide dismutase (Sod1; p < 0.05) compared to control; Bax mRNA expression did not vary. Our results suggest that the increased developmental competence of the embryos could be partly mediated by the EV-endMSCs' ROS scavenger activity.

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This page is a summary of: Extracellular vesicles derived from endometrial human mesenchymal stem cells improve IVF outcome in an aged murine model, Reproduction in Domestic Animals, September 2018, Wiley,
DOI: 10.1111/rda.13314.
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