Ameliorative potential of Quercetin and α-Tocopherol against Cadmium induced dyslipidemia in rats

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The current rate of release of Cd into the environment indicates that Cd intake in human beings will continue to increase and that it will lead to a higher incidence of Cd-related diseases including hypertension, atherosclerosis. Several mechanisms are proposed for the adverse effects of Cd on the cardiovascular system. However, the blood oxidative stress markers, lipid markers, especially plasma total cholesterol, and lipoproteins, are the important risk factors for the development of atherosclerosis. According to medical practitioners, a combination of drugs exhibits augmented protective efficacy than a single drug. To achieve the greatest possible reduction in coronary heart disease (CHD) risk, treatment strategies should be aimed at reducing the elevated levels of circulatory lipids and lipoprotein components. Considering the beneficial effects of QE and á-tocopherol (AT) in CVDs, the present results proved the efficacy of combined pretreatment with QE and AT regulated the levels of lipids, lipoproteins, and enzymes associated with lipid metabolism and plasma lipid peroxidation products in Cd-treated rats.

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