What is it about?

Celiac disease is a genetic disease affecting people of all ages, resulting in small intestine enteropathy. It is considered to be a clinical chameleon. Average prevalence of celiac disease is 1 out of 100 people with data indicating the risk may be as high as 22% for those with first-degree relatives with the disease. Eighty-three percent of people with celiac disease may be undiagnosed. Average duration to diagnosis is 10years. Data indicate that there is a lack of consensus regarding diagnostics and symptomatology. A clinical decision support system (CDSS) was developed using Exsys Corvid for expert analysis (CD-CDSS). The CD-CDSS was divided into symptoms and manifestations with 80 points of navigation, and a serology section.

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Why is it important?

With the average time to diagnosis being 10 years and 83% of those with the disease potentially being undiagnosed, it is critical to obtain a prompt diagnosis. A celiac disease risk estimation and decision-making expert system was successfully developed and evaluated by medical professionals, with 100% agreeing that this CD-CDSS is medically accurate and can guide health care professionals through the diagnostic process.


This research was extremely rewarding. It is critical for diagnosticians to understand the complexities of this disease and reach a diagnosis promptly.

Dr. Robert Pastore
Rutgers University

Read the Original

This page is a summary of: Physician Review of a Celiac Disease Risk Estimation and Decision-Making Expert System, Journal of the American College of Nutrition, May 2019, Taylor & Francis, DOI: 10.1080/07315724.2019.1608477.
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