What is it about?

Correlation analysis revealed interrelationships between VEGF and HbA1c, triglycerides, erythrocyte sedimentation rate and National Institutes of Health Stroke Scale and Rankin scores, whereas principal component analyses identified VEGF as a major loading factor that discriminated good from poor prognosis. Higher levels of VEGF show increased risk of poor prognosis after six months of ischemic stroke.

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Why is it important?

VEGF is not a biomarker of acute stroke, but rather an unfavorable late result, which would influence less recovery at 6 months and possibly vascular dementia.

Perspectives

We hope that this work can be replicated and demonstrate that VEGF is a prognostic angiogenic factor and that, together with other evidence, it may shed light on its role in stroke recovery, sequelae, and vascular dementia.

MD Eduardo Lopez
Universidad Catolica de la Santisima Concepcion

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This page is a summary of: Vascular endothelial growth factor and poor‐prognosis after ischemic stroke, European Journal of Neurology, November 2020, Wiley, DOI: 10.1111/ene.14641.
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