All Stories

  1. Boldine prevents diabetes-induced skeletal muscle dysfunction by inhibiting large-pore channels

    Article • February 2026, openRxiv

    Dr Carlos Escudero

  2. Extracellular Vesicles (EVs) Derived from Senescent Endothelial Cells Promote Platelet Activation

    Article • International Journal of Molecular Sciences, January 2026, MDPI AG

    Dr Carlos Escudero

  3. Boldo Restores Vascularization and Reduces Skeletal Muscle Inflammation in Symptomatic Mice with Dysferlinopathy

    Article • International Journal of Molecular Sciences, October 2025, MDPI AG

    Dr Carlos Escudero

  4. Bioinformatic analysis of placental exomiRs targeting the brain in preeclampsia

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Dr Carlos Escudero

  5. Sex-Specific Neurovascular and Cognitive Deficits in Offspring of Preeclampsia

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Dr Carlos Escudero

  6. Boldo Restores Vascularization and Reduces Inflammation of Skeletal Muscle in Symptomatic Mice with Dysferlinopathy

    Article • August 2025, MDPI AG

    Dr Carlos Escudero

  7. A Changepoint Detection-Based General Methodology for Robust Signal Processing: An Application to Understand Preeclampsia’s Mechanisms

    Article • Bioengineering, June 2025, MDPI AG

    Dr Carlos Escudero

  8. Review: The potential role of placental extracellular vesicles in blood-brain barrier disruption and neuroinflammation in preeclampsia

    Article • Placenta, April 2025, Elsevier

    Dr Carlos Escudero

  9. Plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsia

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Dr Carlos Escudero

  10. The severity of a stroke modifies cellular vesicles that affect cerebral vessels

    Article • The Journal of Physiology, January 2025, Wiley

    MD Eduardo Lopez, Dr Carlos Escudero

  11. hsa-miR-9-5p highly expressed in syncytiotrophoblast-derived extracellular vesicles from early-onset preeclampsia impairs cerebral microvascular endothelial cell pro-angiogenic capacity

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr Carlos Escudero

  12. Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+, and CXCR3+ in Individuals with Acute Myocardial Infarction

    Article • Biomedicines, September 2024, MDPI AG

    Dr Carlos Escudero

  13. Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+ and CXCR3+ in Individuals With Acute Myocardial Infarction

    Article • July 2024, MDPI AG

    Dr Carlos Escudero

  14. Modulation of the activation of endothelial nitric oxide synthase and nitrosative stress biomarkers by aspirin triggered lipoxins: A possible mechanism of action of aspirin in the antiphospholipid syndrome

    Article • American Journal of Reproductive Immunology, July 2023, Wiley

    Dr Carlos Escudero

  15. COVID-19 on Pregnancy Outcomes, Mental Health and Placenta: Focus in Latin America

    Article • January 2023, Springer Science + Business Media

    Dr Carlos Escudero

  16. Language Impairment in Children of Mothers with Gestational Diabetes, Preeclampsia, and Preterm Delivery: Current Hypothesis and Potential Underlying Mechanisms

    Article • January 2023, Springer Science + Business Media

    Dr Carlos Escudero

  17. Extracellular vesicles released upon stimulation with antiphospholipid antibodies: An actual direct procoagulant mechanism or a new factor in the lupus anticoagulant paradox?

    Article • Journal of Autoimmunity, December 2022, Elsevier

    Dr Carlos Escudero

  18. The GPI-Anchored Protein Thy-1/CD90 Promotes Wound Healing upon Injury to the Skin by Enhancing Skin Perfusion

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Dr Carlos Escudero

  19. The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells

    Article • Cancers, September 2022, MDPI AG

    Dr Carlos Escudero, Dr. Francisco Nualart

  20. Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model

    Article • Journal of Cerebral Blood Flow & Metabolism, August 2022, SAGE Publications

    Dr Carlos Escudero

  21. Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia

    Article • Hypertension, August 2022, Wolters Kluwer Health

    Dr Carlos Escudero

  22. Luxofractura compleja del codo con compromiso del húmero distal: Reporte de caso clínico

    Article • Revista Chilena de Ortopedia y Traumatología, August 2022, Thieme Publishing Group

    Dr Carlos Escudero

  23. Loxin Reduced the Inflammatory Response in the Liver and the Aortic Fatty Streak Formation in Mice Fed with a High-Fat Diet

    Article • International Journal of Molecular Sciences, June 2022, MDPI AG

    Dr Carlos Escudero

  24. Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia

    Article • Cells, February 2022, MDPI AG

    Dr Carlos Escudero

  25. Secretome from Human Mesenchymal Stem Cells-Derived Endothelial Cells Promotes Wound Healing in a Type-2 Diabetes Mouse Model

    Article • International Journal of Molecular Sciences, January 2022, MDPI AG

    Dr Carlos Escudero

  26. Disruption of the Blood-Brain Barrier by Extracellular Vesicles From Preeclampsia Plasma and Hypoxic Placentae: Attenuation by Magnesium Sulfate

    Article • Hypertension, November 2021, Wolters Kluwer Health

    Dr Carlos Escudero

  27. Tendencia temporal y evaluación demográfica de hospitalizaciones por osteoartritis

    Article • Revista Chilena de Ortopedia y Traumatología, August 2021, Thieme Publishing Group

    Dr Carlos Escudero

  28. VEGF as a biomarker of poor stroke prognosis

    Article • European Journal of Neurology, November 2020, Wiley

    MD Eduardo Lopez, Dr Carlos Escudero

  29. Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies

    Article • Genes, September 2020, MDPI AG

    Dr Carlos Escudero

  30. Advantages in Wound Healing Process in Female Mice Require Upregulation A2A-Mediated Angiogenesis under the Stimulation of 17β-Estradiol

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Carlos Escudero

  31. The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field

    Article • Expert Review of Clinical Pharmacology, March 2020, Taylor & Francis

    Dr Carlos Escudero

  32. Investigating Maternal Brain Alterations in Preeclampsia: the Need for a Multidisciplinary Effort

    Article • Current Hypertension Reports, August 2019, Springer Science + Business Media

    Dr Carlos Escudero

  33. Impaired placental vessel formation in mice lacking of adenosine A2A receptor

    Article • Placenta, August 2019, Elsevier

    Dr Carlos Escudero

  34. ROLE OF CAVEOLAE IN THE FORMATION OF THE PLACENTAL MICROVASCULATURE AND ITS INTERACTION WITH AQP1 AND VEGFR2

    Article • Placenta, August 2019, Elsevier

    Dr Carlos Escudero

  35. Editorial: Vascular Dysfunction Beyond Pathological Pregnancies. An International Effort Addressed to Fill the Gaps in Latin America

    Article • Frontiers in Physiology, July 2019, Frontiers

    Dr Carlos Escudero

  36. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia

    Article • Pregnancy Hypertension, April 2019, Elsevier

    Dr Carlos Escudero

  37. Mechanisms of Endothelial Dysfunction in Antiphospholipid Syndrome: Association With Clinical Manifestations

    Article • Frontiers in Physiology, December 2018, Frontiers

    Dr Carlos Escudero

  38. Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family

    Article • Frontiers in Physiology, November 2018, Frontiers

    Dr Carlos Escudero

  39. Drug Transport at the Brain and Endothelial Dysfunction in Preeclampsia: Implications and Perspectives

    Article • Frontiers in Physiology, November 2018, Frontiers

    Dr Carlos Escudero

  40. Rol del receptor de adenosina A 2A , óxido nítrico y factor de crecimiento de endotelio vascular en la sepsis: una revisión no sistemática

    Article • Angiología, March 2018, Sociedad Espanola de Nutricion Parenteral y Enteral (SENPE)

    Dr Carlos Escudero

  41. Vascular Dysfunction in Mother and Offspring During Preeclampsia: Contributions from Latin-American Countries

    Article • Current Hypertension Reports, October 2017, Springer Science + Business Media

    Dr Carlos Escudero

  42. Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1

    Article • PLOS One, August 2017, PLOS

    Dr Carlos Escudero

  43. High plasma adenosine levels in overweight/obese pregnant women

    Article • Purinergic Signalling, July 2017, Springer Science + Business Media

    Dr Carlos Escudero

  44. Role of adenosine receptors in the adipocyte–macrophage interaction during obesity

    Article • Endocrinología Diabetes y Nutrición (English ed ), June 2017, Elsevier

    Dr Carlos Escudero

  45. Pro-angiogenic Role of Insulin: From Physiology to Pathology

    Article • Frontiers in Physiology, April 2017, Frontiers

    Dr Carlos Escudero

  46. Apple snack enriched with L-arginine using vacuum impregnation/ohmic heating technology

    Article • Food Science and Technology International, March 2017, SAGE Publications

    Dr Carlos Escudero

  47. High D-glucose–increased nitric oxide generation leads to higher deiodinase 3 mRNA level in human umbilical vein endothelial cells

    Article • Placenta, March 2017, Elsevier

    Dr Carlos Escudero

  48. Is angiogenesis altered in the offspring of mothers with preeclampsia? Potential role of A2A adenosine receptor-nitric oxide-vascular endothelial growth factor pathway

    Article • Placenta, March 2017, Elsevier

    Dr Carlos Escudero

  49. Análisis de los factores de riesgo de muerte neonatal en Chile, 2010-2014

    Article • Revista chilena de pediatría, January 2017, Sociedad Chilena de Pediatria

    Dr Carlos Escudero

  50. Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways

    Article • Frontiers in Physiology, November 2016, Frontiers

    Dr Carlos Escudero

  51. Vascular Regeneration by Endothelial Progenitor Cells in Health and Diseases

    Article • October 2016, IntechOpen

    Dr Carlos Escudero

  52. Adenosine A2A receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies

    Article • Purinergic Signalling, September 2016, Springer Science + Business Media

    Dr Carlos Escudero

  53. l-Arginine-Enriched Apples and Diabetic Control

    Article • August 2016, Springer Science + Business Media

    Dr Carlos Escudero

  54. Overexpression of LOXIN Protects Endothelial Progenitor Cells From Apoptosis Induced by Oxidized Low Density Lipoprotein

    Article • Journal of Cardiovascular Pharmacology, April 2016, Wolters Kluwer Health

    Dr Carlos Escudero

  55. Role of Extracellular Vesicles and microRNAs on Dysfunctional Angiogenesis during Preeclamptic Pregnancies

    Article • Frontiers in Physiology, March 2016, Frontiers

    Dr Carlos Escudero

  56. Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

    Article • Frontiers in Physiology, February 2016, Frontiers

    Dr Carlos Escudero

  57. Letter by Escudero et al Regarding Article, “Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia”

    Article • Circulation, November 2015, Wolters Kluwer Health

    Dr Carlos Escudero

  58. Proposal of a hybrid approach for tumor progression and tumor-induced angiogenesis

    Article • Theoretical Biology and Medical Modelling, July 2015, Springer Science + Business Media

    Dr Carlos Escudero

  59. Adenosine A2 regulate cell proliferation via nitric oxide synthesis in normal and gestational diabetes

    Article • Placenta, April 2015, Elsevier

    Dr Carlos Escudero

  60. Elevated pro-angiogenic phenotype in feto-placental tissue from gestational diabetes mellitus

    Article • Placenta, April 2015, Elsevier

    Dr Carlos Escudero

  61. Editorial: New therapeutic targets for human placental angiogenesis disease

    Article • Frontiers in Pharmacology, December 2014, Frontiers

    Dr Carlos Escudero

  62. Endothelium Trans Differentiated from Wharton's Jelly Mesenchymal Cells Promote Tissue Regeneration: Potential Role of Soluble Pro-Angiogenic Factors

    Article • PLOS One, November 2014, PLOS

    Dr Carlos Escudero

  63. A2A adenosine receptor is required for adenosine-mediated angiogenesis in human umbilical vein endothelial cells from normal and pre-eclamptic cells: preliminary report.

    Article • Placenta, September 2014, Elsevier

    Dr Carlos Escudero

  64. A2B-mediated endothelial cell proliferation is associated with decoupling of the NO and VEGF signaling pathway during pre-eclampsia.

    Article • Placenta, September 2014, Elsevier

    Dr Carlos Escudero

  65. Acoustic Parameters and Salivary IL-6 Levels in Overweight and Obese Teachers

    Article • Journal of Voice, September 2014, Elsevier

    Dr Carlos Escudero

  66. Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes?

    Article • Frontiers in Pharmacology, June 2014, Frontiers

    Dr Carlos Escudero

  67. Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

    Article • Frontiers in Pharmacology, June 2014, Frontiers

    Dr Carlos Escudero

  68. Increased placental angiogenesis in late and early onset pre-eclampsia is associated with differential activation of vascular endothelial growth factor receptor 2

    Article • Placenta, March 2014, Elsevier

    Francisco J. Valenzuela-Melgarejo, Dr Carlos Escudero

  69. Potential Role of A2BAdenosine Receptors on Proliferation/Migration of Fetal Endothelium Derived from Preeclamptic Pregnancies

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Dr Carlos Escudero

  70. Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Dr Carlos Escudero

  71. Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

    Article • Revista médica de Chile, July 2013, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Dr Carlos Escudero

  72. Supplementation with apple enriched with L‐arginine may improve metabolic control and survival rate in alloxan‐induced diabetic rats

    Article • BioFactors, March 2013, Wiley

    Dr Carlos Escudero

  73. Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia

    Article • Purinergic Signalling, November 2012, Springer Science + Business Media

    Dr Carlos Escudero

  74. Elevated concentrations of plasma adenosine in obese children

    Article • BioFactors, August 2012, Wiley

    Dr Carlos Escudero

  75. L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells

    Article • Journal of Cardiovascular Pharmacology, July 2012, Wolters Kluwer Health

    Dr Carlos Escudero

  76. Adenosine A2A and A3 Receptors Are Involved in the Human Endothelial Progenitor Cells Migration

    Article • Journal of Cardiovascular Pharmacology, May 2012, Wolters Kluwer Health

    Dr Carlos Escudero

  77. Adverse perinatal outcomes after the February 27th 2010 Chilean earthquake

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, April 2012, Taylor & Francis

    Dr Carlos Escudero

  78. Adenosine plasma levels in the fetoplacental circulation in preeclampsia

    Article • American Journal of Obstetrics and Gynecology, April 2012, Elsevier

    Dr Carlos Escudero

  79. The placenta in preeclampsia

    Article • Pregnancy Hypertension, April 2012, Elsevier

    Dr Carlos Escudero

  80. Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, March 2011, Taylor & Francis

    Dr Carlos Escudero

  81. IFPA Meeting 2010 Workshop Report I: Immunology; Ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics

    Article • Placenta, March 2011, Elsevier

    Dr Alicia E Damiano, Dr Carlos Escudero, Gendie Lash

  82. Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia

    Article • Current Vascular Pharmacology, October 2009, Bentham Science Publishers

    Dr Carlos Escudero

  83. Potential Cell Signalling Mechanisms Involved in Differential Placental Angiogenesis in Mild and Severe Pre-Eclampsia

    Article • Current Vascular Pharmacology, October 2009, Bentham Science Publishers

    Dr Carlos Escudero

  84. Adenosine mediates transforming growth factor‐beta 1 release in kidney glomeruli of diabetic rats

    Article • FEBS Letters, September 2009, Wiley

    Dr Carlos Escudero

  85. Reduced l-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia

    Article • Placenta, July 2009, Elsevier

    Dr Carlos Escudero

  86. Human Equilibrative Nucleoside Transporters 1 and 2 may be Differentially Modulated by A2B Adenosine Receptors in Placenta Microvascular Endothelial Cells from Pre-eclampsia

    Article • Placenta, September 2008, Elsevier

    Dr Carlos Escudero

  87. A Hypothesis for Preeclampsia: Adenosine and Inducible Nitric Oxide Synthase in Human Placental Microvascular Endothelium

    Article • Placenta, June 2008, Elsevier

    Dr Carlos Escudero

  88. Endothelial Dysfunction and Preeclampsia

    Article • American Journal of Hypertension, September 2007, Oxford University Press (OUP)

    Dr Carlos Escudero

  89. Equilibrative Nucleoside (ENTs) and Cationic Amino Acid (CATs) Transporters: Implications in Foetal Endothelial Dysfunction in Human Pregnancy Diseases

    Article • Current Vascular Pharmacology, January 2007, Bentham Science Publishers

    Dr Carlos Escudero

  90. Hierro, oxígeno y desarrollo placentario en la génesis de la preeclampsia: Efectos de la altura en Ecuador

    Article • Revista médica de Chile, April 2006, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Dr Carlos Escudero

  91. NO in Early Pregnancy and Development of Preeclampsia

    Article • Hypertension, April 2006, Wolters Kluwer Health

    Dr Carlos Escudero

  92. Abnormal release of nitric oxide from nitrosoprotein in preeclampsia

    Article • International Journal of Gynecology & Obstetrics, January 2006, Wiley

    Dr Carlos Escudero

  93. C‐reactive protein during normal pregnancy and preeclampsia

    Article • International Journal of Gynecology & Obstetrics, March 2005, Wiley

    Dr Carlos Escudero

  94. Intraplatelet Cyclic Guanosine‐3′,5′‐Monophosphate Levels During Pregnancy and Preeclampsia

    Article • Hypertension in Pregnancy, January 2004, Taylor & Francis

    Dr Carlos Escudero

  95. Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels

    Article • Free Radical Biology and Medicine, December 2003, Elsevier

    Dr Carlos Escudero

  96. Seroprevalence of antibodies to chlamydia pneumoniae in women with preeclampsia

    Article • Obstetrics and Gynecology, July 2003, Wolters Kluwer Health

    Dr Carlos Escudero

  97. Physiological changes in platelet aggregation and nitric oxide levels during menstrual cycle in healthy women

    Article • Nitric Oxide, November 2002, Elsevier

    Dr Carlos Escudero

  98. Elevated C‐reactive protein and pro‐inflammatory cytokines in Andean women with pre‐eclampsia

    Article • International Journal of Gynecology & Obstetrics, November 2001, Wiley

    Dr Carlos Escudero