What is it about?

This review is about how a microorganism such as GBS colonizes the female vagina mucosa of both pregnant and non pregnant women. From the studies we reviewed, diabetes mellitus resulted increased GBS biofilm formation and in turn increased infection in both pregnant and non pregnant women. Overall, pregnant women were more susceptible to the infection compared to non pregnant women.

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Why is it important?

The literature has little or few information about how environmental nutrients such as glucose can influence or affect GBS vaginal colonization as well as the mechanism involved. This review sought to address this issue by combining what is already available in the literature, comparing the data and adding our own thoughts to the subject above.


This review helps bring to awareness the increased pathogenicity of GBS in pregnant women with underlying conditions such as diabetes mellitus, posing a greater risk factor for neonatal infection. Hence, greater attention should be given to pregnant women who are susceptible to gestational diabetes during pregnancy to ensure that both maternal and neonatal health is not compromised.

Joel Omage
Vanderbilt University Medical Center

Read the Original

This page is a summary of: Group B streptococcal infection of the genitourinary tract in pregnant and non‐pregnant patients with diabetes mellitus: An immunocompromised host or something more?, American Journal of Reproductive Immunology, October 2021, Wiley,
DOI: 10.1111/aji.13501.
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