Analysis of extracellular vesicles from endometrial-derived mesenchymal stem cells

What is it about?

The results from the proteomic analysis of extracellular vesicles from endometrial-derived mesenchymal stem cells (EV-endMSCs) and the classification by Reactome pathways allowed us to identify proteins closely related with the fertilization process. Moreover, the supplementation of the embryo culture medium with EV-endMSCs improved the developmental competence of the embryos as well as the total blastomere count.

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Why is it important?

We demonstrate that EV-endMSCs increase the quality of the embryos, and according to proteomic and genomic analysis, presumably by modulating the expression of antioxidant enzymes and promoting pluripotent activity. Therefore, EV-endMSCs could be a valuable tool in human assisted reproduction improving the developmental competence of aged oocytes and increasing the odds of implantation and subsequent delivery.