What is it about?
Cervical cancer is the third most common malignant tumor and has become one of the major causes of cancer mortality. According to studies conducted recently; carbonic anhydrase IX (CAIX) is a particularly attractive target for cancer therapy, in part because it is limited as expressed in normal tissues on the other hand in a variety of solid neoplasms are overexpressed. Despite new methods and drugs to treat cervical cancer, there is a wide range of chemicals and natural products that have not yet been studied and tested as anticancer agents. - The aromatic sulfonamide derivative (S-1) is considered a new compound with great anti-cancer potential. - For the first time, the apoptotic, cytotoxic, and genotoxic properties of S-1 were studied in cervical cancer cell lines at various concentrations.
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Why is it important?
Evaluation of the anticancer potential of a novel sulfonamide inhibitor of carboxylic anhydrase IX on cervical cancer cells was performed. The current original study was performed using a standard assay. Apoptosis and cell cycle induction were measured by flow cytometric analysis, and intracellular free radical induction was determined by reactive oxygen species (ROS) analyses.
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This page is a summary of: Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells, Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis, DOI: 10.1080/14756366.2019.1579805.
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