A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin

  • Sem Tamara, Vojtech Franc, Albert J. R. Heck
  • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences
  • DOI: 10.1073/pnas.2002483117

How unique is our plasma proteome?

Photo by MaxeyLash on Unsplash

Photo by MaxeyLash on Unsplash

What is it about?

Ever wondered if glycoproteoform heterogeneity varies between genotypes and oligomeric states of Haptoglobin? Our data show that it does, both in glycosylation and proteolytic processing, with implications for Hemoglobin scavenging

Why is it important?

Serum haptoglobin protein (Hp) scavenges toxic hemoglobin (Hb) leaked into the bloodstream from leaking erythrocytes. We show that each person has different variants (i.e. proteoforms) of Hp in their serum, and reveal how all these variants in oligomerization, glycosylation and processing influence its scavenging activity. Our data also show that haptoglobin can only be considered a viable biomarker when all its proteoforms are considered.

Perspectives

Albert Heck
Universiteit Utrecht

Our genomes are unique, but also our serum proteomes are unique/personalized. Improvements is personalized medicine diagnostics should thus also consider the proteoform profiles of important serum biomarkers

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http://dx.doi.org/10.1073/pnas.2002483117

The following have contributed to this page: Albert Heck