Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

Z. Sabouri, P. Schofield, K. Horikawa, E. Spierings, D. Kipling, K. L. Randall, D. Langley, B. Roome, R. Vazquez-Lombardi, R. Rouet, J. Hermes, T. D. Chan, R. Brink, D. K. Dunn-Walters, D. Christ, C. C. Goodnow
  • Proceedings of the National Academy of Sciences, May 2014, Proceedings of the National Academy of Sciences
  • DOI: 10.1073/pnas.1406974111

What is it about?

The binding site of an antibody could be obscured by a post-translation modification - glycosylation. So any hypermutation of an antibody in the germinal centre that affects a potential glycosylation site could affect antibody binding and therefore could moderate the positive and negative selection processes that a B cell has to pass through.

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http://dx.doi.org/10.1073/pnas.1406974111

The following have contributed to this page: Professor Deborah K Dunn-Walters