All Stories

  1. The ageing human B cell repertoire: a failure of selection?

    Article • Clinical & Experimental Immunology, October 2015, Wiley

    Professor Deborah K Dunn-Walters

  2. B cell repertoire ageing

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, July 2015, Royal Society Publishing

    Professor Deborah K Dunn-Walters

  3. IgM B cells important in ageing

    Article • Annals of the New York Academy of Sciences, July 2015, Wiley

    Professor Deborah K Dunn-Walters

  4. Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus

    Article • European Journal of Immunology, June 2015, Wiley

    Professor Deborah K Dunn-Walters

  5. Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response

    Article • Experimental Hematology, June 2015, Elsevier

    Professor Deborah K Dunn-Walters

  6. Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus

    Article • Molecular Immunology, June 2015, Elsevier

    Professor Deborah K Dunn-Walters

  7. Assessment of B Cell Repertoire in Humans

    Article • January 2015, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  8. Immunoglobulin Gene Repertoire Diversification and Selection in the Stomach – From Gastritis to Gastric Lymphomas

    Article • Frontiers in Immunology, June 2014, Frontiers

    Professor Deborah K Dunn-Walters

  9. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

    Article • Proceedings of the National Academy of Sciences, May 2014, Proceedings of the National Academy of Sciences

    Professor Deborah K Dunn-Walters

  10. Understanding the Mechanisms of Immune System Aging: Immune System Cell Development and Antibody Repertoires

    Article • January 2014, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  11. Immunogenetics and transplantation

    Article • Current Opinion in Immunology, October 2013, Elsevier

    Professor Deborah K Dunn-Walters

  12. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    Article • Physical Biology, August 2013, Institute of Physics Publishing

    Professor Deborah K Dunn-Walters

  13. Human lymphocyte repertoires in ageing

    Article • Current Opinion in Immunology, August 2013, Elsevier

    Professor Deborah K Dunn-Walters

  14. Yersinia enterocolitica Provides the Link between Thyroid-Stimulating Antibodies and Their Germline Counterparts in Graves' Disease

    Article • The Journal of Immunology, April 2013, The American Association of Immunologists

    Professor Deborah K Dunn-Walters

  15. PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies

    Article • Experimental and Molecular Pathology, February 2013, Elsevier

    Professor Deborah K Dunn-Walters

  16. Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis

    Article • Annals of the Rheumatic Diseases, October 2012, BMJ

    Professor Deborah K Dunn-Walters

  17. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient

    Article • Leukemia, August 2012, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  18. Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination

    Article • Frontiers in Immunology, January 2012, Frontiers

    Professor Deborah K Dunn-Walters

  19. B cell immunosenescence: different features of naive and memory B cells in elderly

    Article • Biogerontology, August 2011, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  20. Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages

    Article • Aging Cell, August 2011, Wiley

    Professor Deborah K Dunn-Walters

  21. B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

    Article • Ageing Research Reviews, April 2011, Elsevier

    Professor Deborah K Dunn-Walters

  22. IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans

    Article • Gastroenterology, March 2011, Elsevier

    Professor Deborah K Dunn-Walters

  23. The Relationship between CD27 Negative and Positive B Cell Populations in Human Peripheral Blood

    Article • Frontiers in Immunology, January 2011, Frontiers

    Professor Deborah K Dunn-Walters

  24. The ageing immune system and its clinical implications

    Article • Reviews in Clinical Gerontology, December 2010, Cambridge University Press

    Professor Deborah K Dunn-Walters

  25. Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases

    Article • Journal of Autoimmunity, December 2010, Elsevier

    Professor Deborah K Dunn-Walters

  26. Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses

    Article • International Immunology, November 2010, Oxford University Press (OUP)

    Professor Deborah K Dunn-Walters

  27. Immune Responses: Primary and Secondary

    Article • September 2010, Wiley

    Professor Deborah K Dunn-Walters

  28. B cell repertoire and ageing

    Article • Current Opinion in Immunology, August 2010, Elsevier

    Professor Deborah K Dunn-Walters

  29. Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity

    Article • Lupus, May 2010, SAGE Publications

    Professor Deborah K Dunn-Walters

  30. High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations

    Article • Blood, May 2010, American Society of Hematology

    Professor Deborah K Dunn-Walters

  31. Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function

    Article • Immunology, February 2010, Wiley

    Professor Deborah K Dunn-Walters

  32. Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC

    Article • European Journal of Immunology, January 2010, Wiley

    Professor Deborah K Dunn-Walters

  33. The ageing B cell population: Composition and function

    Article • Biogerontology, November 2009, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  34. Mechanisms of immunosenescence

    Article • Immunity & Ageing, July 2009, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  35. Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?

    Article • Molecular Immunology, July 2009, Elsevier

    Professor Deborah K Dunn-Walters

  36. B cells and aging: molecules and mechanisms

    Article • Trends in Immunology, July 2009, Elsevier

    Professor Deborah K Dunn-Walters

  37. Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue

    Article • Seminars in Immunology, June 2009, Elsevier

    Professor Deborah K Dunn-Walters

  38. B-cell diversity decreases in old age and is correlated with poor health status

    Article • Aging Cell, February 2009, Wiley

    Professor Deborah K Dunn-Walters

  39. B-cell clonal diversification and gut-lymph node trafficking in ulcerative colitis revealed using lineage tree analysis

    Article • European Journal of Immunology, September 2008, Wiley

    Professor Deborah K Dunn-Walters

  40. Lambda Light Chain Revision in the Human Intestinal IgA Response

    Article • The Journal of Immunology, July 2008, The American Association of Immunologists

    Professor Deborah K Dunn-Walters

  41. A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

    Article • PLoS ONE, June 2008, PLOS

    Professor Deborah K Dunn-Walters

  42. Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: Chronic activation, normal selection

    Article • Cellular Immunology, December 2006, Elsevier

    Professor Deborah K Dunn-Walters

  43. Immunoglobulin variable-region gene mutational lineage tree analysis: Application to autoimmune diseases

    Article • Autoimmunity Reviews, April 2006, Elsevier

    Professor Deborah K Dunn-Walters

  44. Antibody Quality in Old Age

    Article • Rejuvenation Research, March 2006, Mary Ann Liebert Inc

    Professor Deborah K Dunn-Walters

  45. Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV2 and IGKV3

    Article • Immunogenetics, October 2005, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  46. Hypermutation at A-T Base Pairs: The A Nucleotide Replacement Spectrum Is Affected by Adjacent Nucleotides and There Is No Reverse Complementarity of Sequences Flanking Mutated A and T Nucleotides

    Article • The Journal of Immunology, October 2005, The American Association of Immunologists

    Professor Deborah K Dunn-Walters

  47. Immunoglobulin light-chain genes in the rhesus macaque II: lambda light-chain germline sequences for subgroups IGLV1, IGLV2, IGLV3, IGLV4 and IGLV5

    Article • Immunogenetics, September 2005, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  48. Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3

    Article • Immunogenetics, April 2005, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  49. Dual role for Bcl-2 in antibody affinity maturation

    Article • Nature Cell Biology, April 2005, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  50. The ageing gut

    Article • Mechanisms of Ageing and Development, December 2004, Elsevier

    Professor Deborah K Dunn-Walters

  51. Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees

    Article • Biosystems, August 2004, Elsevier

    Professor Deborah K Dunn-Walters

  52. Effects of age on antibody affinity maturation

    Article • Biochemical Society Transactions, April 2003, Portland Press Ltd.

    Professor Deborah K Dunn-Walters

  53. Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees

    Article • European Journal of Immunology, July 2002, Wiley

    Professor Deborah K Dunn-Walters

  54. Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis

    Article • Gut, July 2002, BMJ

    Professor Deborah K Dunn-Walters

  55. The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees

    Article • Developmental Immunology, January 2002, Hindawi Publishing Corporation

    Professor Deborah K Dunn-Walters

  56. Somatic hypermutation and B-cell lymphoma

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, January 2001, Royal Society Publishing

    Professor Deborah K Dunn-Walters, Christian Thiede

  57. Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in-frame and highly mutated and most kappa genes are highly mutatedwhen in-frame and minimally mutated when out-of-frame

    Article • European Journal of Immunology, October 2000, Wiley

    Professor Deborah K Dunn-Walters

  58. Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT)

    Article • Mechanisms of Ageing and Development, May 2000, Elsevier

    Professor Deborah K Dunn-Walters

  59. Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions

    Article • Molecular Immunology, February 2000, Elsevier

    Professor Deborah K Dunn-Walters

  60. Characteristics of Human IgA and IgM Genes Used by Plasma Cells in the Salivary Gland Resemble Those Used in Duodenum But Not Those Used in the Spleen

    Article • The Journal of Immunology, February 2000, The American Association of Immunologists

    Professor Deborah K Dunn-Walters

  61. Human tonsillar germinal center T cells are a diverse and widely disseminated population

    Article • European Journal of Immunology, November 1999, Wiley

    Professor Deborah K Dunn-Walters

  62. Human tonsillar germinal center T cells are a diverse and widely disseminated population

    Article • European Journal of Immunology, November 1999, Wiley

    Professor Deborah K Dunn-Walters

  63. Characteristics of IgVH genes used by human intestinal plasma cells from childhood

    Article • Immunology, August 1999, Wiley

    Professor Deborah K Dunn-Walters

  64. Biased JH usage in plasma cell immunoglobulin gene sequences from colonic mucosa in ulcerative colitis but not in Crohn's disease

    Article • Gut, March 1999, BMJ

    Professor Deborah K Dunn-Walters

  65. Somatic hypermutation and B-cell malignancies

    Article • The Journal of Pathology, January 1999, Wiley

    Professor Deborah K Dunn-Walters

  66. Somatic hypermutation and B‐cell malignancies

    Article • The Journal of Pathology, January 1999, Wiley

    Professor Deborah K Dunn-Walters

  67. Strong intrinsic biases towards mutation and conservation of bases in human IgVHgenes during somatic hypermutation prevent statistical analysis of antigen selection

    Article • Immunology, November 1998, Wiley

    Professor Deborah K Dunn-Walters

  68. Human marginal-zone B cells

    Article • Immunology Today, September 1998, Elsevier

    Professor Deborah K Dunn-Walters

  69. Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation

    Article • Human Pathology, June 1998, Elsevier

    Professor Deborah K Dunn-Walters

  70. Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells

    Article • European Journal of Immunology, November 1997, Wiley

    Professor Deborah K Dunn-Walters

  71. Immunoglobulin genes from human duodenal and colonic plasma cells are mutated

    Article • Biochemical Society Transactions, May 1997, Portland Press Ltd.

    Professor Deborah K Dunn-Walters

  72. Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches

    Article • European Journal of Immunology, February 1997, Wiley

    Professor Deborah K Dunn-Walters

  73. A new humanIghV4.21-related pseudogene capable ofVDJ rearrangement

    Article • Immunogenetics, September 1996, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  74. Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections

    Article • European Journal of Immunology, June 1996, Wiley

    Professor Deborah K Dunn-Walters

  75. A new human IghV4.21-related pseudogene capable of V D J rearrangement

    Article • Immunogenetics, March 1996, Springer Science + Business Media

    Professor Deborah K Dunn-Walters

  76. Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue

    Article • Molecular Pathology, February 1996, BMJ

    Professor Deborah K Dunn-Walters

  77. Discovery of "IgM Memory" B cells

    Article • The Journal of Experimental Medicine, August 1995, Rockefeller University Press

    Professor Deborah K Dunn-Walters

  78. Location and sequence of rearranged immunoglobulin genes in human thymus

    Article • European Journal of Immunology, February 1995, Wiley

    Professor Deborah K Dunn-Walters

  79. B-Cells and Antibodies in Old Humans

    Article • Springer Science + Business Media

    Professor Deborah K Dunn-Walters